ChemicalBook--->CAS DataBase List--->133894-48-1

133894-48-1

133894-48-1 Structure

133894-48-1 Structure
IdentificationMore
[Name]

Chlorotripyrrolidinophosphonium hexafluorophosphate
[CAS]

133894-48-1
[Synonyms]

CHLOROTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE
PYCLOP
Chlorotripyrrolidinophosphoniumhexafluorophosphat
PYCLOP CHLOROTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE
PYCIOP
[EINECS(EC#)]

628-539-2
[Molecular Formula]

C12H24ClF6N3P2
[MDL Number]

MFCD00210035
[Molecular Weight]

421.73
[MOL File]

133894-48-1.mol
Chemical PropertiesBack Directory
[Melting point ]

145-148°C
[storage temp. ]

2-8°C
[solubility ]

soluble in Chloroform, Methanol
[form ]

Crystalline Powder
[color ]

White to yellow
[Sensitive ]

Moisture Sensitive
[BRN ]

6842341
[Major Application]

peptide synthesis
[InChI]

InChI=1S/C12H24ClN3P.F6P/c13-17(14-7-1-2-8-14,15-9-3-4-10-15)16-11-5-6-12-16;1-7(2,3,4,5)6/h1-12H2;/q+1;-1
[InChIKey]

BSCYRXJVGSZNKX-UHFFFAOYSA-N
[SMILES]

[P+5]([F-])([F-])([F-])([F-])([F-])[F-].[P+](N1CCCC1)(N1CCCC1)(N1CCCC1)Cl
[CAS DataBase Reference]

133894-48-1(CAS DataBase Reference)
Safety DataBack Directory
[Symbol(GHS) ]

Corrosion (GHS05)
GHS05
[Signal word ]

Danger
[Hazard statements ]

H318-H314
[Precautionary statements ]

P260-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501-P280-P305+P351+P338-P310-P260h-P301+P330+P331-P303+P361+P353-P501a
[Hazard Codes ]

Xi,C
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
R34:Causes burns.
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
[RIDADR ]

UN 1759 8/PG 2
[WGK Germany ]

3
[F ]

10-21
[REACH Registrations]

Active
[HazardClass ]

8
[PackingGroup ]

II
[HS Code ]

29339900
[Storage Class]

8A - Combustible corrosive hazardous materials
Hazard InformationBack Directory
[Uses]

Reagent for:
Peptide coupling reactions and synthesis of coupling reagents
Sequence selective peptide recognition
Synthesis of condensing reagents
Synthesis of heterocyclic β-sheet ligands
[Uses]

Celltransmission 20, 2, 2004.
[Uses]

Crystalline reagent for peptide coupling of a-alkylated N-Fmoc and N-Z-amino acids in high yield and without racemization.
[Preparation]

Preparation of chlorotripyrrolidinophosphonium hexafluorophosphate: addition of chlorine to a diethyl ether solution of tripyrrolidinophosphine, then addition of KPF6 in water. Addition of tripyrrolidinophosphine oxide to a DCM solution of phosphoryl trichloride, then addition of KPF6 in water.
[reaction suitability]

reaction type: Coupling Reactions
Spectrum DetailBack Directory
[Spectrum Detail]

Chlorotripyrrolidinophosphonium hexafluorophosphate(133894-48-1)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

133894-48-1(sigmaaldrich)
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