| Identification | Back Directory | [Name]
N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide dihydrochloride | [CAS]
1347744-96-0 | [Synonyms]
A-412997 dihydrochloride
2-(4-(Pyridin-2-yl)piperidin-1-yl)-N-(m-tolyl)acetamide dihydrochloride | [Molecular Formula]
C19H24ClN3O | [MDL Number]
MFCD22373818 | [MOL File]
1347744-96-0.mol | [Molecular Weight]
345.87 |
| Chemical Properties | Back Directory | [storage temp. ]
room temp | [solubility ]
H2O: soluble20mg/mL, clear | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: 20mg/mL, clear | [InChI]
1S/C19H23N3O.2ClH/c1-15-5-4-6-17(13-15)21-19(23)14-22-11-8-16(9-12-22)18-7-2-3-10-20-18;;/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,21,23);2*1H | [InChIKey]
KIGNSSHMCNBHQX-UHFFFAOYSA-N | [SMILES]
Cl.Cl.N2(CCC(CC2)c3ncccc3)CC(=O)Nc1cc(ccc1)C |
| Hazard Information | Back Directory | [Uses]
N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide-d7 Dihydrochloride is labelled N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide Dihydrochloride (M320725) which acts as a selective agonist against dopamine D4 receptors, which affect cognitive performance and activity. | [Biological Activity]
a 412997 dihydrochloride is a selective agonist of dopamine d4 receptor with ki values of 7.9 and 12.1 nm for human and rat d4 receptors, respectively [1].dopamine d4 receptor is a g protein-coupled receptor and is activated by dopamine. it plays an important role in cognition, parkinsons disease, addictive behaviors and so on.a 412997 dihydrochloride is a selective dopamine d4 receptor agonist. in calcium flux functional assays, a-412997 activated the rat dopamine d4 receptor with ec50 value and intrinsic activity of 28.4 nm and 0.83, respectively [1].in spontaneous hypertensive rat pups (shr pups), a 412997 significantly increased acquisition in the 5-trial repeated acquisition model. in the short-term social memory, a 412997 significantly shortened the second investigation time. in wistar rats and dawley rats, a 412997 (3 μm/kg, 10 μm/kg) increased locomotor activity [2]. in rats, a 412997 reduced non-rapid eye movement (nrem) sleep duration and increased waking duration. also, a 412997 reduced rapid eye movement (rem) sleep duration and delayed the onset of rem sleep [3]. | [storage]
Desiccate at RT | [References]
[1]. moreland rb, patel m, hsieh gc, et al. a-412997 is a selective dopamine d4 receptor agonist in rats. pharmacol biochem behav, 2005, 82(1): 140-147.
[2]. browman ke, curzon p, pan jb, et al. a-412997, a selective dopamine d4 agonist, improves cognitive performance in rats. pharmacol biochem behav, 2005, 82(1): 148-155.
[3]. nakazawa s, nakamichi k, imai h, et al. effect of dopamine d4 receptor agonists on sleep architecture in rats. prog neuropsychopharmacol biol psychiatry, 2015, 63: 6-13. |
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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