| Identification | Back Directory | [Name]
(R)-N-Boc-2-Hydroxymethylmorpholine | [CAS]
135065-71-3 | [Synonyms]
(R)-N-BOC-2-HYDROXYMETHYLMORPHOLINE
(R)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE
(R)-2-hydroxyMethyl-4-BOC-Morpholine
(R)-N-Boc-2-hydroxymethylmorpholine,99%
(R)/(S)-N-Boc-2-hydroxymethylmorpholine
(R)-N-Boc-2-hydroxymethylmorpholine,99%e.e.
(R)-4-t-butoxycarbonyl-2-(hydroxymethyl)morpholine
Tert-Butyl(R)-2-(Hydroxymethyl)Morpholine-4-Carboxylate
(R)-N-Boc-2-Hydroxymethylmorpholine ISO 9001：2015 REACH
tert-butyl (2R)-2-(hydroxymethyl)morpholine-4-carboxylate
tert-Butyl (2R)-2-(hydroxymethyl)morpholine-4-carboxylate 95+%
(R)-2-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester
2-(Hydroxymethyl)morpholine-4-carboxylic acid (R)-tert-butyl ester
(2R)-2-(Hydroxymethyl)-4-morpholinecarboxylic acid tert-butyl ester
4-Morpholinecarboxylic acid, 2-(hydroxyMethyl)-, 1,1-diMethylethyl ester, (2R)- | [Molecular Formula]
C10H19NO4 | [MDL Number]
MFCD09260605 | [MOL File]
135065-71-3.mol | [Molecular Weight]
217.26 |
| Chemical Properties | Back Directory | [Melting point ]
59-61 °C | [Boiling point ]
321 °C | [density ]
1.118 | [Fp ]
148 °C | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
14.36±0.10(Predicted) | [InChI]
InChI=1S/C10H19NO4/c1-10(2,3)15-9(13)11-4-5-14-8(6-11)7-12/h8,12H,4-7H2,1-3H3/t8-/m1/s1 | [InChIKey]
FJYBLMJHXRWDAQ-MRVPVSSYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCO[C@@H](CO)C1 |
| Hazard Information | Back Directory | [Uses]
(R)-N-Boc-2-hydroxymethylmorpholine is used for preparation of inhibitors of Checkpoint Kinase 1 through template screening. | [Synthesis]
Intermediate 111 (19.8 g, 64.4 mmol) was stirred and reacted for 16 h under hydrogen atmosphere with 10% Pd/C (1.98 g, 1.86 mmol) as catalyst. Upon completion of the reaction, the catalyst was removed by vacuum filtration and the filtrate was concentrated under reduced pressure to afford 13.98 g (100% yield) of (R)-N-Boc-2-hydroxymethylmorpholine, the product was a colorless viscous oil that crystallized upon standing. The 1H NMR (250 MHz, chloroform-d) data of the product were as follows: δ [ppm] 3.98 - 3.75 (m, 3H), 3.73 - 3.41 (m, 4H), 3.03 - 2.83 (m, 1H), 2.82 - 2.65 (m, 1H), 2.12 (t, J = 5.9 Hz, 1H), 1.45 (s, 9H). | [References]
[1] Heterocycles, 1993, vol. 35, # 1, p. 105 - 109
[2] Patent: WO2016/91776, 2016, A1. Location in patent: Page/Page column 290
[3] Patent: WO2008/124575, 2008, A1. Location in patent: Page/Page column 112; 113-114
[4] Patent: US2010/184805, 2010, A1. Location in patent: Page/Page column 30-31
[5] Patent: WO2007/70201, 2007, A1. Location in patent: Page/Page column 176 |
|
|