| Identification | Back Directory | [Name]
4-methoxy-3-methylaniline | [CAS]
136-90-3 | [Synonyms]
4-AMINO-2-METHYLANISOLE
4-METHOXY-3-METHYLANILINE
3-Methyl-4-methoxyaniline
4-methoxy-3-methylbenzenamine
3-Methyl-4-methoxybenzenamine
BenzenaMine, 4-Methoxy-3-Methyl-
4-AMINO-24-AMINO-2-METHYLANISOLE-METHYLANISOLE
4-AMino-2-Methylanisole[4-Methoxy-3-Methylaniline] | [Molecular Formula]
C8H11NO | [MDL Number]
MFCD07779234 | [MOL File]
136-90-3.mol | [Molecular Weight]
137.18 |
| Chemical Properties | Back Directory | [Melting point ]
57-60℃ | [Boiling point ]
252.03°C (rough estimate) | [density ]
1.0630 (rough estimate) | [refractive index ]
1.5360 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
5.32±0.10(Predicted) | [color ]
Dark Red to Black | [InChI]
1S/C8H11NO/c1-6-5-7(9)3-4-8(6)10-2/h3-5H,9H2,1-2H3 | [InChIKey]
NFWPZNNZUCPLAX-UHFFFAOYSA-N | [SMILES]
COc1ccc(N)cc1C |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
20/21/22-36/37/38 | [Safety Statements ]
26-36/37/39 | [WGK Germany ]
3 | [HS Code ]
2922290090 | [Storage Class]
13 - Non Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
4-Methoxy-3-methylaniline is used in preparation of triamine pyrimidine derivatives as antitumor agents. | [Synthesis]
The synthesis of 4-methoxy-3-methylaniline is as follows:
4-Methoxy-3-methyl-phenylamine10% Palladium on carbon (10% Pd/C) (1.5 g) was added to a solution of 1 -methoxy-2- methyl-4-nitrobenzene (9.5 g, 57 mmol) in methanol (100 ml_). The mixture was stirred under a hydrogen atmosphere (1 atm.) at room temperature for 16 h. The mixture was filtered through a pad of CELITE and the filtrate was evaporated in vacuo to yield 4- methoxy-3-methylphenylamine (8.0 g, 57 mmol, 100%).
 | [References]
[1] Patent: WO2006/95014, 2006, A1. Location in patent: Page/Page column 33
[2] Angewandte Chemie - International Edition, 2017, vol. 56, # 21, p. 5886 - 5889
[3] Angew. Chem., 2017, vol. 129, p. 5980 - 5983,4
[4] Synthesis, 1995, # 4, p. 397 - 408
[5] Journal of the American Chemical Society, 1946, vol. 68, p. 1551 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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