| Identification | Back Directory | [Name]
SPERMINE NONOATE | [CAS]
136587-13-8 | [Synonyms]
NOC-22
SPER/NO
SPERMINE NONOATE
Spermine NONOate,97%
SpermineNONOate,SPER/NO
Spermine Bis(NO) Adduct
SPERMINE/NITRIC OXIDE COMPLEX
SPERMINE BIS (NITRIC OXIDE) ADDUCT
SPERMINE/NITRIC OXIDE COMPLEX (SPER/NO)
Spermine-Nitric oxide complex hydrate
N-(2-AMINOETHYL)-N-(2-HYDROXY-2-NITROSOHYDRAZINO)-1,2-ETHYLENEDIAMINE
N-(2-AMINOETHYL)-N-(2-HYDROXY-3-NITROSOHYDRAZINO)-1,2-ETHYLENEDIAMINE
N-[4-[1-(3-AMINOPROPYL)-2-HYDROXY-2-NITROSOHYDRAZINO]BUTYL]-1,3-PROPANEDIAMINE
N1-[4-[1-(3-Aminopropyl)-2-hydroxy-2-nitrosohydrazinyl]butyl]-1,3-propanediamine
N'-(3-aMinopropyl)-N'-(4-((3-aMinopropyl)aMino)butyl)-N-hydroxynitrous hydrazide hydrate
(Z)-1-[N-[3-AMINOPROPYL]-N-[4-(3-AMINOPROPYL-AMMONIO)BUTYL]-AMINO]-DIAZEN-1-IUM-1,2-DIOLATE
(Z)-1-[N-(3-AMMONIOPROPYL)-N-[4-(3-AMINOPROPYLAMMONIO) BUTYL]-AMINO]DIAZEN-1-IUM-1,2-DIOLATE
SPER/NO, Spermine NONOate, N-[4-[1-(3-Aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl]-1,3-propanediamine | [Molecular Formula]
C10H26N6O2 | [MDL Number]
MFCD00210215 | [MOL File]
136587-13-8.mol | [Molecular Weight]
262.35 |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
105-107°C | [Boiling point ]
405.6°C (rough estimate) | [density ]
1.0879 (rough estimate) | [refractive index ]
1.7000 (estimate) | [storage temp. ]
-20°C | [solubility ]
methanol: ≥1mg/mL | [form ]
White solid | [pka]
5.47±0.69(Predicted) | [color ]
white | [Stability:]
Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Buffer solutions are not stable and must be prepared immediately before use. |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
A reagent which releases Nitric Oxide into aqueous solutions at controlled rates for in vitro studies | [Biological Activity]
A stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC 50 = 6.2 μ M for relaxation of rabbit aorta, and t ?=39 min at 37癈, pH 7.4, aqueous solution). | [Description]
Spermine NONOate (136587-13-8) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner.? ? The half-life of Spermine NONOate in 0.1 M phosphate buffer at pH 7.4 is 39 min at 37 °C, or 230 min at room temperature.1? ? Dissociation is essentially instantaneous at a pH of 5.0. | [General Description]
Complex of nitric oxide (NO) with spermine. Convenient reagent for preparing aqueous solutions of NO. Half-life (t?) of NO release = 230 min (PBS, pH 7.4, 22°C). | [Biochem/physiol Actions]
Product does not compete with ATP. | [References]
1) Keefer et al. (1996), “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol., 268 281 |
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