ChemicalBook--->CAS DataBase List--->137178-88-2

137178-88-2

Request For Quotation
137178-88-2 Structure

137178-88-2 Structure
IdentificationBack Directory
[Name]

5-BROMOPYRIDINE-2-CARBONYL CHLORIDE
[CAS]

137178-88-2
[Synonyms]

5-Bromo-2-(chlorocarbonyl)pyridine
5-BROMOPYRIDINE-2-CARBONYL CHLORIDE
2-Pyridinecarbonyl chloride, 5-bromo-
5-BroMo-pyriMidine-2-carbonyl chloride
5-Bromopyridine-2-carbonyl chloride ,97%
5-Bromopyridine-2-carbonyl chloride, tech
5-BroMopyridine-2-carbonyl chloride, tech grade
5-BROMOPYRIDINE-2-CARBONYL CHLORIDE ISO 9001：2015 REACH
5-Bromo-2-(chlorocarbonyl)pyridine, 5-Bromopicolinoyl chloride
[Molecular Formula]

C6H3BrClNO
[MDL Number]

MFCD07368290
[MOL File]

137178-88-2.mol
[Molecular Weight]

220.45
Chemical PropertiesBack Directory
[Boiling point ]

250 ºC
[density ]

1.760
[Fp ]

105 ºC
[storage temp. ]

Inert atmosphere,2-8°C
[form ]

Solid
[pka]

-1.86±0.10(Predicted)
[Sensitive ]

Moisture Sensitive
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Thionyl chloride-->Toluene-->n-Butyllithium-->2,5-Dibromopyridine-->5-Bromo-2-pyridinecarboxylic Acid-->Dichloromethane-->Oxalyl chloride-->N,N-Dimethylformamide
[Preparation Products]

5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER-->piperidin-1-yl(5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)Methanone-->5-Bromo-N-cyclopropylpyridine-2-carboxamide-->5-BROMO-PYRIDINE-2-CARBOXYLIC ACID DIETHYLAMIDE
Safety DataBack Directory
[HazardClass ]

8
[HazardClass ]

IRRITANT
[HS Code ]

29333990
Hazard InformationBack Directory
[Chemical Properties]

Brown solid
[Synthesis]

5-Bromo-2-pyridinecarboxylic Acid

30766-11-1

5-BROMOPYRIDINE-2-CARBONYL CHLORIDE

137178-88-2

General procedure for the synthesis of 5-bromo-pyridine-2-carbonyl chloride from 2-carboxylic acid-5-bromopyridine: To a solution of dichloromethane (80 mL) containing 5-bromo-pyridine-2-carboxylic acid (0.05 mmol), oxalyl chloride (0.24 mmol) and N,N-dimethylformamide (5 drops) were slowly added dropwise at room temperature. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give 5.4 g (100% yield) of 5-bromo-pyridine-2-carbonyl chloride.

[References]

[1] Patent: CN103130792, 2016, B. Location in patent: Paragraph 0533
[2] Patent: WO2014/164749, 2014, A1. Location in patent: Page/Page column 312
[3] Patent: WO2017/221100, 2017, A1. Location in patent: Paragraph 00262
[4] Tetrahedron, 2005, vol. 61, # 45, p. 10748 - 10756
[5] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 7, p. 2074 - 2079
Spectrum DetailBack Directory
[Spectrum Detail]

5-BROMOPYRIDINE-2-CARBONYL CHLORIDE(137178-88-2)FT-IR
137178-88-2 suppliers list
Company Name: Zhuhai Aobokai Biomedical Technology Co., Ltd.  Gold
Telephone: 400-0628126
Website: www.aobchem.com.cn/
Company Name: J & K SCIENTIFIC LTD.  
Telephone: 18210857532 18210857532
Website: https://www.jkchemical.com
Company Name: Alfa Aesar  
Telephone: 400-6106006
Website: http://chemicals.thermofisher.cn
Company Name: JinYan Chemicals(ShangHai) Co.,Ltd.  
Telephone: 13817811078
Website: www.jingyan-chemical.com
Company Name: Nanjing Chemlin Chemical Co., Ltd  
Telephone: 025-83697070 13770331960
Website: www.echemlin.cn
Company Name: Nanjing Vital Chemical Co., Ltd.  
Telephone: Please Send Email 18652950785
Website: www.chemicalbook.com/ShowSupplierProductsList15337/0_EN.htm
Company Name: 9ding chemical ( Shanghai) Limited  
Telephone: 4009209199
Website: www.9dingchem.com
Company Name: SynAsst Chemical.  
Telephone: 021-60343070
Website: www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm
Company Name: Shanghai Yolne Chemical Co., Ltd.  
Telephone: 021-62960152
Website: http://www.yolne.com
Company Name: Shanghai Balmxy Pharmaceutical Co., Ltd  
Telephone: 021-24206007 13764915196
Website: http://www.balmxy.com/
Company Name: YouCoChem (Beijing) Chemical Technology Co., Ltd.  
Telephone: 18800159827
Website:
Company Name: Chengdu Research Accelerators Technology Co., Ltd.  
Telephone: 028-64353063
Website: www.chemicalbook.com/ShowSupplierProductsList17155/0_EN.htm
Company Name: Amadis Chemical Company Limited  
Telephone: 571-89925085
Website: http://www.amadischem.com
Company Name: AAB-PHARMA LIMITED  
Telephone: 025-66800956 18800000000
Website: http://www.njdmchem.com/
Company Name: Aikon International Limited  
Telephone: 025-66113011 19370895928
Website: www.aikonchem.com
Company Name: ANHUI WITOP BIOTECH CO., LTD  
Telephone: +8618071025641
Website: www.chemicalbook.com/ShowSupplierProductsList418627/0_EN.htm
Company Name: Dideu Industries Group Limited  
Telephone: +8617392712697
Website: www.dideu.com
Company Name: Dayang Chem (Hangzhou) Co.,Ltd.  
Telephone: +86-0571-88938639 17705817739
Website: www.dycnchem.com/
Tags:137178-88-2 Related Product Information
9002-86-2 7447-40-7 98-88-4 94695-48-4 6452-47-7 3430-13-5 7647-14-5 140-72-7 933-88-0 10043-52-4 12125-02-9 67-48-1 31181-90-5 122-04-3 124-63-0