| Identification | Back Directory | [Name]
5-BROMOPYRIDINE-2-CARBONYL CHLORIDE | [CAS]
137178-88-2 | [Synonyms]
5-Bromo-2-(chlorocarbonyl)pyridine
5-BROMOPYRIDINE-2-CARBONYL CHLORIDE
2-Pyridinecarbonyl chloride, 5-bromo-
5-BroMo-pyriMidine-2-carbonyl chloride
5-Bromopyridine-2-carbonyl chloride ,97%
5-Bromopyridine-2-carbonyl chloride, tech
5-BroMopyridine-2-carbonyl chloride, tech grade
5-BROMOPYRIDINE-2-CARBONYL CHLORIDE ISO 9001：2015 REACH
5-Bromo-2-(chlorocarbonyl)pyridine, 5-Bromopicolinoyl chloride | [Molecular Formula]
C6H3BrClNO | [MDL Number]
MFCD07368290 | [MOL File]
137178-88-2.mol | [Molecular Weight]
220.45 |
| Chemical Properties | Back Directory | [Boiling point ]
250 ºC | [density ]
1.760 | [Fp ]
105 ºC | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
Solid | [pka]
-1.86±0.10(Predicted) | [Sensitive ]
Moisture Sensitive |
| Hazard Information | Back Directory | [Chemical Properties]
Brown solid | [Synthesis]
General procedure for the synthesis of 5-bromo-pyridine-2-carbonyl chloride from 2-carboxylic acid-5-bromopyridine: To a solution of dichloromethane (80 mL) containing 5-bromo-pyridine-2-carboxylic acid (0.05 mmol), oxalyl chloride (0.24 mmol) and N,N-dimethylformamide (5 drops) were slowly added dropwise at room temperature. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give 5.4 g (100% yield) of 5-bromo-pyridine-2-carbonyl chloride. | [References]
[1] Patent: CN103130792, 2016, B. Location in patent: Paragraph 0533
[2] Patent: WO2014/164749, 2014, A1. Location in patent: Page/Page column 312
[3] Patent: WO2017/221100, 2017, A1. Location in patent: Paragraph 00262
[4] Tetrahedron, 2005, vol. 61, # 45, p. 10748 - 10756
[5] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 7, p. 2074 - 2079 |
|
| Company Name: |
Alfa Aesar
|
| Tel: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
|