1374639-75-4

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1374639-75-4 Structure

Identification	Back Directory
[Name] LEE011 (succinate)
[CAS] 1374639-75-4
[Synonyms] LEE011 (succinate) Ribociclib succite Ribociclib succinate Ribociclib Succinate (Kisqali) RIBOCICLIB SUCCINATE (LEE011 SUCCINATE) LEE-011 succinate salt, Ribociclib succinate salt 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate
[Molecular Formula] C27H36N8O5
[MOL File] 1374639-75-4.mol
[Molecular Weight] 552.64

Chemical Properties	Back Directory
[Melting point ] >160oC (dec.)
[storage temp. ] Refrigerator
[solubility ] DMSO (Slightly), Methanol (Slightly)
[form ] Solid
[color ] Pale Beige

Safety Data	Back Directory
[Symbol(GHS) ] GHS06,GHS08,GHS09
[Signal word ] Danger
[Hazard statements ] H301-H315-H319-H372-H400
[Precautionary statements ] P273-P301+P310-P305+P351+P338-P314

Hazard Information	Back Directory
[Uses] LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models.

Spectrum Detail	Back Directory
[Spectrum Detail] LEE011 (succinate)(1374639-75-4)¹HNMR

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