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Pyrrole Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Products Intro: Product Name:Pyrrole
Purity:98%(Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Products Intro: Product Name:Pyrrole
Company Name: Jiangsu Qingquan Chemical Co., Ltd.
Tel: +86-571-86589381/86589382/86589383
Products Intro: Product Name:Pyrrole
Company Name: career henan chemical co
Tel: +86-371-86658258
Products Intro: Product Name:Pyrrole
Purity:99% Package:1KG;1USD
Tel: 13867897135
Products Intro: Product Name:Pyrrole

Lastest Price from Pyrrole manufacturers

  • Pyrrole
  • US $1.00 / KG
  • 2018-08-11
  • CAS:109-97-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: Customized
Pyrrole Basic information
Heterocyclic compound Chemical Properties Uses Production methods Hazards & Safety Information
Product Name:Pyrrole
Synonyms:PYRROLE;1-Aza-2,4-cyclopentadiene;Divinyleneimine;Monopyrrole;Parzate;Pyrrhol;Pyrrol;4-methyl(di-pyrrol-2-yl-methtyl)pyridinium iodide
Product Categories:Porphyrins;Pyrrole;Halogenated;Organohalides;Porphyrin Building Blocks;Alkoxy;Organoborons;Functional Materials;Pyrroles (for Conduting Polymer Research);Reagents for Conducting Polymer Research;Flavour &Fragrance Intermediates
Mol File:109-97-7.mol
Pyrrole Structure
Pyrrole Chemical Properties
Melting point -23 °C
Boiling point 131 °C(lit.)
density 0.967 g/mL at 25 °C(lit.)
vapor density 2.31 (vs air)
vapor pressure 8.7 hPa (20 °C)
refractive index n20/D 1.508(lit.)
Fp 92 °F
storage temp. 0-6°C
solubility 60g/l
pka15(at 25℃)
form Liquid
color Clear almost colorless to brownish
PH>6 (10g/l, H2O, 20℃)
explosive limit3.10-14.8%(V)
Water Solubility 60 g/L (20 ºC)
Sensitive Air & Light Sensitive
Merck 14,8014
BRN 1159
Stability:Stable. Incompatible with strong acids, strong oxidizing agents. Combustible.
CAS DataBase Reference109-97-7(CAS DataBase Reference)
NIST Chemistry ReferencePyrrole(109-97-7)
EPA Substance Registry System1H-Pyrrole(109-97-7)
Safety Information
Hazard Codes T
Risk Statements 10-20-25-41
Safety Statements 26-37/39-45-39-24-16
RIDADR UN 1992 3/PG 3
WGK Germany 2
RTECS UX9275000
Autoignition Temperature550 °C
HazardClass 3
PackingGroup III
HS Code 29339900
Hazardous Substances Data109-97-7(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 137 mg/kg
MSDS Information
SigmaAldrich English
ACROS English
ALFA English
Pyrrole Usage And Synthesis
Heterocyclic compoundPyrrole is a five-membered heterocyclic compound which contains one nitrogen atom, it is colorless liquid at room temperature, naturally presents in coal tar and bone oil, turns black color quickly in the air, it has significant irritant odor. The relative density is 0.9691, the boiling point is 130~131℃, freezing point is-24℃. It is almost insoluble in water and dilute alkali solution, soluble in alcohol, ether, benzene and mineral acid solution. It is very stable for alkali, it easily polymerizes into dark red resin trimer in the presence of small amount of inorganic acid, when it is stored, it exposes to light or air will cause resinification. Pyrrole vapor meets loose pieces which moistened with hydrochloric acid can show red, this is called loose piece reaction (pine flakes reaction; pine splint test), it can be used to identify pyrrole. 5 atoms on the pyrrole ring are sp2 hybrid, they are in the same plane, one pair not shared electrons of the nitrogen atom occupy the p-orbital, four carbon atoms and p-orbital are parallel and overlapping, forming 5 atoms, 6 π electrons closed conjugated system, it has aromatic character, prone to electrophilic substitution reactions. Thus, alkalinity of nitrogen atom in pyrrole is small (pKb13.6); On the contrary, combination of hydrogen on the nitrogen atom is weak acid. In addition, pyrrole ring with benzene and other aromatic compounds are same, it can conduct nitration, sulfonation, diazo coupling reaction, Friedel-Crafts type acylation. This reaction can get 2-substituted compound.
Nitrogen atom of pyrrole molecule is sp2 hybridized, unshared electron pair occupys p-orbitals, p-orbitals with parallel 4 sp2 hybridized carbon atoms overlap to form a six-electron conjugated system, it has aromatic character, electrophilic substitution reactions can occur.
Unshared electron pairs of pyrrole nitrogen atoms involve in the conjugated ring system, and binding capacity with H + is very weak, it is not showing alkaline. Since the electron density on the nitrogen atom is relatively lower, the hydrogen atom attached to the nitrogen atom can leave in the form of positive ions, thus pyrrole has faintly acid. Ionization constant Ka = 10-15, it can react with solid potassium hydroxide to form a salt.
Many pyrrole derivatives are important drugs and have strong physiologically active substances, such as chlorophyll, heme.
Pyrrole is basic structural unit of heme, chlorophyll, bile pigments, some amino acids, several alkaloids and some enzymes, these compounds have strong physiological activity and drugs functional. Vitamin B12, glycopyrrolate, kainic acid (drive roundworm medicine), clindamycin (antibiotic) drugs contain hydrogenated pyrrole ring structure. Since 1979, it found that flexible conductive polymer film can be obtained by electrochemical oxidation of pyrrole, the conductivity is 104S/m, and it had good stability.
Chemical PropertiesIt is colorless to yellowish liquid, long-term storage in the process is easy to expose the action of light and the polymerize to turn brown. It has warm sweet fruity of nuts and esters. Boiling point is 130 ℃ (decomposition), a flash point is 39 ℃, a melting point is-24 ℃. It is soluble in alcohol, ether, benzene, acid and most of the non-volatile oil, insoluble in water and dilute alkali.
Uses(1) Spices. The main type use is the preparation of fruit and spice flavors.
(2) It is used for the synthesis of pharmaceuticals and fine chemicals such as perfume
(3) Its derivatives are widely used in organic synthesis, pharmaceuticals, pesticides, spices, rubber vulcanization accelerator, epoxy curing agents of raw materials
(4) It is used as chromatographic analysis standard material, it is also used in organic synthesis and pharmaceutical industry.
(5) It can be used for the pharmaceutical, perfume and other synthetic intermediates.
(6) It is widely used in the synthesis of pharmaceuticals, pesticides and dyes. In the pharmaceutical industry can be used for synthesis of Barossa Star (Irloxacin), meters pyrrole acid (Piromidic), pyrrole pentanone (Pyrovalerone), pyrrole Cain (Pyrrocaine) and set off disease (TMT) and the like.
(7) It can be used to test gold selenite and silicic acid. Determination of chromate, gold, iodine salt, mercury, selenious acid, silicon and vanadium.
Production methods1, furan and ammonia is as raw materials, γ-alumina is as catalyst, the gas-phase catalytic reaction can get it.
2, After total heat fractionation of the bones oil and sulfuric acid, it converts into its potassium salt (C4H4NK), it is washed with ether and treated with water and then dried, fractionation can derive.It can be obtained by pyrolysis of galactose ammonium in glycerol or mineral oil from pyrolysis.
Hazards & Safety InformationCategory: Flammable liquid
Toxicity grading: Highly toxic
Intraperitoneal acute toxicity-mouse LD50: 98 mg/kg; Oral-rabbit LDL0: 147 mg/kg
Flammability hazard characteristics: it is flammable when in case of fire, heat, oxidants; combustion produces toxic fumes of nitrogen oxides
Storage characteristics: Treasury ventilation low-temperature drying; it should be stored separately with oxidants.
Extinguishing agent: Dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.
Chemical Propertiescolourless to brown liquid with chloroform odour
UsesManufacture of pharmaceuticals.
DefinitionChEBI: A tautomer of pyrrole that has the double bonds at positions 2 and 4.
HazardModerate fire risk. Toxic by ingestion and inhalation.
Safety ProfilePoison by ingestion, subcutaneous, and intraperitoneal routes. Flammable liquid when exposed to heat or flame; can react with oxilzing materials. To fight fire, use foam, CO2, dry chemical. Violent reaction with 2-nitrobenzaldehyde. When heated to decomposition it emits highly toxic fumes of NOx.
Purification MethodsDry pyrrole with NaOH, CaH2 or CaSO4. Fractionally distil it under reduced pressure from CaH2. Store it under nitrogen as it turns brown in air. Redistil it immediately before use. The picrate forms orange-red crystals with m 69o(dec). [Beilstein 20 H 4, 20 I 3, 20 II 3, 20 III/IV 61, 20/5 V 3.]
Tag:Pyrrole(109-97-7) Related Product Information
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