| Identification | Back Directory | [Name]
Propargyl-PEG5-alcohol | [CAS]
87450-10-0 | [Synonyms]
87450-10-0
Alkyne-PEG4-OH
PROPARGYL-PEG5-OH
Propargyl-PEG4-OH
Propyne-PEG4-alcohol
Propargyl-PEG5-alcohol
3,6,9,12-Tetraoxapentadec-14-yn-1-ol
Propargyl-PEG5-alcohol ISO 9001：2015 REACH
2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethanol | [Molecular Formula]
C11H20O5 | [MDL Number]
MFCD22201537 | [MOL File]
87450-10-0.mol | [Molecular Weight]
232.27 |
| Chemical Properties | Back Directory | [Boiling point ]
324.4±32.0 °C(Predicted) | [density ]
1.071±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [form ]
Liquid | [pka]
14.36±0.10(Predicted) | [color ]
Light yellow to brown | [InChI]
InChI=1S/C11H20O5/c1-2-4-13-6-8-15-10-11-16-9-7-14-5-3-12/h1,12H,3-11H2 | [InChIKey]
WQMJFCWQBPUZCK-UHFFFAOYSA-N | [SMILES]
C(O)COCCOCCOCCOCC#C |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG5-alcohol enables Click Chemistry reactions with azide compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. | [Uses]
Propargyl-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Synthesis]
In a three-necked flask equipped with a magnetic stirrer, a reflux condenser tube and a thermometer, 1.4 g of potassium tert-butoxide, 2.0 g of tetrapolyethylene glycol, 3.0 g of propargyl bromide and 95 mL of tetrahydrofuran were added respectively, prot | [IC 50]
PEGs | [References]
[1] Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1. |
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