| Identification | Back Directory | [Name]
Propargyl-PEG8-bromide | [CAS]
2055046-25-6 | [Synonyms]
Propargyl-PEG8-bromide
3,6,9,12,15,18,21,24-Octaoxaheptacos-26-yne, 1-bromo- | [Molecular Formula]
C19H35BrO8 | [MDL Number]
MFCD29042377 | [MOL File]
2055046-25-6.mol | [Molecular Weight]
471.38 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG8-bromide is a PEG reagent containing an alkyne group and a bromide group. The alkyne group canreacts with azide-bearing compounds or biomolecules in Click Chemistry reactions under the catalyzation of copper. The PEG spacer increases water-solubility of the molecule in aqueous media. | [Uses]
Propargyl-PEG8-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-bromide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG8-bromide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Non-cleavable Linker; PEGs | [References]
[1] Suzanne AKERS-RODRIGUEZ, et al. Compositions and methods for the treatment of bacterial infections. WO2019126353A2. |
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