| Identification | More | [Name]
Tocopherol | [CAS]
1406-18-4 | [Synonyms]
5,7,8-TRIMETHYLTOCOL
ALL-RAC-ALPHA-TOCOPHEROL
ALPHA-DL-TOCOPHEROL
(+/-)-ALPHA-TOCOFEROL
(+/-)-ALPHA-TOCOPHEROL
ALPHA-TOCOPHEROLUM
A-TOCOPHEROL
DL-2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRIDECYL)-6-CHROMANOL
DL-5,7,8-TRIMETHYLTOCOL
DL-ALL-RAC-ALPHA-TOCOPHEROL
DL-ALPHA-TOCOPHEROL
DL-ALPHA TOCOPHERYL ACETATE 500
D, L-A-TOCOPHEROL
DL-PHYTOGERMINE
DL-PROFECUNDIN
DL-TOCOPHEROL
DL-VITAMIN E
DL-VITAMIN E ALCOHOL
IRGANOX E 201
RAC-ALPHA-TOCOPHEROL | [EINECS(EC#)]
215-798-8 | [Molecular Formula]
C29H50O2 | [MDL Number]
MFCD00072051 | [Molecular Weight]
430.71 | [MOL File]
1406-18-4.mol |
| Chemical Properties | Back Directory | [Definition]
(vitamin E). Any of a group of related substances (α-, β-, γ-, andΔ-tocopherol) that constitute vitamin E. The α-form (which occurs naturally as the d-isomer) is the most potent. Occurs naturally in plants, especially wheat germ. All are derivatives of dihydrobenzo-γ-pyran and differ from each other only in the number and position of methyl groups. Vitamin E is required by certain rodents for normal reproduction. Muscular and central nervous system depletion along with generalized edema are deficiency symptoms in all animals. It is not required as a dietary supplement for humans.
| [Appearance]
Viscous oils. Soluble in fats; insoluble
in water. Stable to heat in the absence of oxygen,
to strong acids, and to visible light; unstable to UV
light, alkalies, and oxidation. | [Melting point ]
292 °C | [storage temp. ]
0-6°C | [Odor]
Typical vegetable oil | [LogP]
10.962 (est) | [Uses]
Fat-soluble vitamin E, which is a light yellow oil readily degradable by heat. As a vitamin, it is essential for normal muscle growth and prevents vitamin A destruction by deterioration. It also functions as an antioxidant. It prevents the oxidation of certain fatty acids and is stable unless the food becomes rancid. Vegetable oils contain a higher concentration of natural antioxidants, including tocopherols, than animal fats and are thus more stable. Tocopherol is obtained from vegetable oils, beans, eggs, and milk. It is also termed alpha-tocopherol. | [CAS DataBase Reference]
1406-18-4(CAS DataBase Reference) | [NIST Chemistry Reference]
«alpha»-Tocopherol(1406-18-4) | [EPA Substance Registry System]
1406-18-4(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
Viscous oils. Soluble in fats; insoluble
in water. Stable to heat in the absence of oxygen,
to strong acids, and to visible light; unstable to UV
light, alkalies, and oxidation. | [Pharmacology]
The antioxidant effects of tocopherol can be translated into different changes at the pharmacodynamic level. In vitro studies have shown that this antioxidant activity can produce modification in protein kinase C (PKC) which will later be translated into an inhibition of cell death. Some other derivate effects are the anti-inflammatory properties of tocopherol which can be related to the modulation of cytokines or prostaglandins, prostanoids and thromboxanes.
| [Toxicology]
Tocopherol is considered as non-toxic but if very high doses are administered, there are reports of hemorrhagic activity. Reproductive and developmental toxicity tests are negative. These negative results were also observed in the analysis of mutagenicity and carcinogenicity.
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