| Identification | Back Directory | [Name]
Bromo-PEG5-t-butyl ester | [CAS]
1415800-38-2 | [Synonyms]
Br-PEG5-COOtBu
Bromo-PEG5-Boc
CAS_1415800-38-2
Br-PEG5-butyl ester
Br-PEG5-CH2CH2COOtBu
Br-PEG5-t-butyl ester
tert-Butyl 1-bromo-3,6,9,12,15-pentaoxaoctadecan-18-oate
4,7,10,13,16-Pentaoxaoctadecanoic acid, 18-bromo-, 1,1-dimethylethyl ester | [Molecular Formula]
C17H33BrO7 | [MDL Number]
MFCD22683304 | [MOL File]
1415800-38-2.mol | [Molecular Weight]
429.34 |
| Chemical Properties | Back Directory | [Boiling point ]
453.9±40.0 °C(Predicted) | [density ]
1.200±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [solubility ]
Soluble in DMSO, DCM,DMF | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Bromo-PEG5-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Bromo-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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