| Identification | Back Directory | [Name]
Bromo-PEG3-t-butyl ester | [CAS]
782475-37-0 | [Synonyms]
782475-37-0
Br-PEG3-COOtBu
Br-PEG3-C2-Boc
CAS_782475-37-0
Bromo-peg3-t-butyl
Br-PEG3-CH2CH2COOtBu
Br-PEG3-t-butyl ester
tert-butyl 3-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)propanoate
Propanoic acid, 3-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C13H25BrO5 | [MDL Number]
MFCD22574821 | [MOL File]
782475-37-0.mol | [Molecular Weight]
341.24 |
| Chemical Properties | Back Directory | [Boiling point ]
375.4±27.0 °C(Predicted) | [density ]
1.223±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [solubility ]
Soluble in DCM | [form ]
Liquid | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C13H25BrO5/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h4-11H2,1-3H3 | [InChIKey]
ISAHSVMMFPHXFG-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)CCOCCOCCOCCBr |
| Hazard Information | Back Directory | [Description]
Bromo-PEG3-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Br-PEG3-C2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
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