| Identification | Back Directory | [Name]
Bromo-PEG8-t-butyl ester | [CAS]
1623792-00-6 | [Synonyms]
Br-PEG8-COOtBu
Bromo-PEG8-Boc
CAS_1623792-00-6
Br-PEG8-CH2CH2COOtBu
Br-PEG8-t-butyl ester
Bromo-PEG8-t-butyl ester
Bromo-PEG9-t-butyl ester
4,7,10,13,16,19,22,25-Octaoxaheptacosanoic acid, 27-bromo-, 1,1-dimethylethyl ester
tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate | [Molecular Formula]
C23H45BrO10 | [MDL Number]
MFCD26793748 | [MOL File]
1623792-00-6.mol | [Molecular Weight]
561.5 |
| Hazard Information | Back Directory | [Description]
Bromo-PEG8-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Bromo-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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