| Identification | Back Directory | [Name]
Propargyl-PEG4-NHS ester | [CAS]
1428629-70-2 | [Synonyms]
1428629-70-2
Alkyne-PEG4-NHS
Alkyne-PEG3-NHS ester
Propargyl-PEG4-NHS ester
Propargyl-PEG3-CH2CH2COONHS
Propargyl-PEG4-NHS ester,Alkyne-PEG4-NHS
2,5-dioxopyrrolidin-1-yl 4,7,10,13-tetraoxahexadec-15-ynoate
2,5-dioxopyrrolidin-1-yl 4,7,10,13-tetraoxahexadec-15-yn-1-oate
4,7,10,13-Tetraoxahexadec-15-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C16H23NO8 | [MDL Number]
MFCD22380743 | [MOL File]
1428629-70-2.mol | [Molecular Weight]
357.36 |
| Chemical Properties | Back Directory | [Boiling point ]
463.1±55.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
Storage temp. -20°C | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Viscous Liquid | [color ]
Colorless to light yellow | [Appearance]
colorless to yellowish oil |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG4-NHS ester is an amine reactive PEG linker with an alkyne group. Under the copper catalyzation, alkyne group can react with azide-bearing biomolecules to form a stable triazole linkage. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
Propargyl-PEG4-NHS ester is a nonclaevable 4-unit PEG linker for antibody-agent-conjugation (ADC). Propargyl-PEG4-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Non-cleavable Linker |
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