| Identification | Back Directory | [Name]
Azido-PEG5-NHS ester | [CAS]
1433996-86-1 | [Synonyms]
N3-PEG5-NHS
N3-PEG5-SPA
AZIDO-PEG5-NHS
Azido-PEG5-NHS ester
N3-PEG5-CH2CH2COONHS
Azido-PEG5-NHS Ester,N3-PEG5-NHS
2,5-dioxopyrrolidin-1-yl 1-azido-3,6,9,12,15-pentaoxaoctadecan-18-oate | [Molecular Formula]
C17H28N4O9 | [MDL Number]
MFCD24539474 | [MOL File]
1433996-86-1.mol | [Molecular Weight]
432.43 |
| Hazard Information | Back Directory | [Description]
Azido-PEG5-NHS ester is a click chemistry PEG reagent. The azide (N3) group can react with alkyne, such as BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
Azido-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG5-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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