| Identification | Back Directory | [Name]
Azide-PEG5-t-butyl ester | [CAS]
1415800-41-7 | [Synonyms]
Azide-PEG5-Boc
Azido-PEG5-COOtBu
N3-PEG5-CH2CH2COOtBu
Azido-PEG5-tBu Ester
N3-?PEG5-?t-?butyl ester
Azide-PEG5-t-butyl ester
Azido-PEG6-t-butyl ester
tert-butyl 1-azido-3,6,9,12,15-pentaoxaoctadecan-18-oate | [Molecular Formula]
C17H33N3O7 | [MDL Number]
MFCD22683303 | [MOL File]
1415800-41-7.mol | [Molecular Weight]
391.47 |
| Hazard Information | Back Directory | [Description]
Azide-PEG5-t-butyl ester is a click reagent containing an azide with azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. | [Uses]
Azide-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG5-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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