| Identification | More | [Name]
1,3-Dichloro-4-fluorobenzene | [CAS]
1435-48-9 | [Synonyms]
1,3-DICHLORO-4-FLUOROBENZENE
1,3-DICHLOROFLUOROBENZENE
2,4-DICHLORO-1-FLUOROBENZENE
2,4-DICHLOROFLUOROBENZENE
Benzene,2,4-dichloro-1-fluoro-
2,4-DichloroFluorobenzene99.5%
2,4-Dichlorofluorobenzene 99%
2,4-Dichlorofluorobenzene99%
2,4-DICHLOROFLUOROBENZENECIPROFLOXACIN | [EINECS(EC#)]
406-160-1 | [Molecular Formula]
C6H3Cl2F | [MDL Number]
MFCD00000580 | [Molecular Weight]
164.99 | [MOL File]
1435-48-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colourless to yellow liquid | [Melting point ]
-23 °C | [Boiling point ]
172-174 °C(lit.) | [density ]
1.409 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.525(lit.)
| [Fp ]
98 °F
| [storage temp. ]
Flammables area | [form ]
clear liquid | [color ]
Colorless to Light yellow to Light orange | [Specific Gravity]
1.409 | [Water Solubility ]
insoluble | [BRN ]
2500791 | [InChI]
InChI=1S/C6H3Cl2F/c7-4-1-2-6(9)5(8)3-4/h1-3H | [InChIKey]
BDJZCCWUSOZUQG-UHFFFAOYSA-N | [SMILES]
C1(F)=CC=C(Cl)C=C1Cl | [CAS DataBase Reference]
1435-48-9(CAS DataBase Reference) | [NIST Chemistry Reference]
1,3-Dichloro-4-fluorobenzene(1435-48-9) |
| Safety Data | Back Directory | [Symbol(GHS) ]
   
GHS02,GHS07,GHS09,GHS08 | [Signal word ]
Warning | [Hazard statements ]
H226-H302-H315-H411-H227-H373 | [Precautionary statements ]
P210-P233-P240-P241+P242+P243-P264-P270-P273-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P391-P403+P235-P501-P210e-P260-P280a-P301+P312a-P501a | [Hazard Codes ]
Xn,N,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R38:Irritating to the skin.
R48/20/22:Harmful: danger of serious damage to health by prolonged exposure through inhalation and if swallowed .
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S16:Keep away from sources of ignition-No smoking .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
3
| [Hazard Note ]
Irritant | [REACH Registrations]
Inactive | [HazardClass ]
9 | [PackingGroup ]
III | [HS Code ]
29039990 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Fluorobenzene-->4-Nitrobenzoyl chloride-->3-Chloro-4-fluoroaniline-->3-Chloro-4-fluoronitrobenzene-->2,4-Dinitrofluorobenzene-->5-Chloro-2-fluoronitrobenzene-->2,4-Dichloroaniline-->2,4-dichloroanilinium chloride | [Preparation Products]
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid-->2,4-Dichloro-5-fluoro-3-methoxybenzoyl chloride-->2,4-Dichloro-5-fluoro-3-methoxybenzoic acid-->1-(2,4-Dichloro-5-fluoro-3-methoxyphenyl)ethanone-->3-Bromo-2,6-dichloro-5-fluoro-1-methoxybenzene-->Ciprofloxacin-->1-Amino-2,4-dichloro-5-fluoro-3-methoxybenzene-->2,4-Dichloro-5-fluoro-3-methoxynitro-benzene-->Ciprofloxacin hydrochloride-->2,4-Dichloro-5-fluorobenzoic acid-->3-Bromo-2,4-dichloro-5-fluoronitrobenzene-->2,4-Dichloro-5-fluoroacetophenone-->2,4-Dichloro-5-fluoronitrobenzene-->2,6-Dichloro-3-fluoroacetophenone-->1-(2,6-Dichloro-3-fluorophenyl)ethanol |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colourless to yellow liquid | [Uses]
1, 3-dichloro-4-fluorobenzene is a multifunctional chemical reagent. Its benzene ring structure formula contains fluorine and chlorine functional groups and can be used in various reaction systems. It is widely applied in the field of organic synthesis. | [Synthesis]
The general procedure for the synthesis of 2,4-dichlorofluorobenzene from 3-chloro-4-fluoronitrobenzene is as follows: 240 g (1.37 mol) of 3-chloro-4-fluoronitrobenzene was added to a 250 ml four-necked flask and the temperature of the reaction system was raised to 170°C. The temperature of the reaction system was raised to 170°C. The reaction system was then purged with dry chlorine. Dry chlorine gas was slowly passed in the temperature range of 170 to 180 °C. The reaction process was carried out by distillation for 8 hours and the distillate was collected. The distillate was subsequently washed with water and then with alkali to a weakly basic pH. The organic phase was separated and purified by distillation, resulting in 207 g of 2,4-dichlorofluorobenzene with 99.8% purity and 91.7% yield. | [References]
[1] Patent: CN102249881, 2016, B. Location in patent: Paragraph 0020; 0075-0076
[2] Recueil des Travaux Chimiques des Pays-Bas, 1932, vol. 51, p. 98,109 |
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