ChemicalBook--->CAS DataBase List--->144-29-6

144-29-6

144-29-6 Structure

144-29-6 Structure
IdentificationMore
[Name]

PIPERAZINE CITRATE
[CAS]

144-29-6
[Synonyms]

ANTEPAR
CITRIC ACID SESQUIPIPERAZINE SALT
PARAZINE
PIPERAZINE CITRATE
PIPERAZINE CITRATE SALT
TRIPIPERAZINE DICITRATE
PiperazineCitrateBp
Tripiperazindicitrat
PIPERAZINE CITARATE SALT
PIPERAZINE CITRATE/TRIPIPERAZINE DICITRATE
Citric acid hydrate sesquipiperazine salt
3Piperazine·2citric acid
[EINECS(EC#)]

205-622-8
[Molecular Formula]

C24H46N6O14
[MDL Number]

MFCD00038961
[Molecular Weight]

642.65
[MOL File]

144-29-6.mol
Chemical PropertiesBack Directory
[Melting point ]

183-187℃
[Boiling point ]

208℃[at 101 325 Pa]
[density ]

0.741[at 20℃]
[vapor pressure ]

56.928Pa
[storage temp. ]

Inert atmosphere,Room Temperature
[solubility ]

Soluble in DMSO
[form ]

powder to crystal
[color ]

White to Almost white
[Water Solubility ]

54g/L at 24℃
[Merck ]

7464
[LogP]

-1.15
[CAS DataBase Reference]

144-29-6(CAS DataBase Reference)
[EPA Substance Registry System]

Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2) (144-29-6)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
[WGK Germany ]

1
[RTECS ]

TL3485000
[HS Code ]

29335990
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Piperazine-->PIPERAZINE HEXAHYDRATE
Hazard InformationBack Directory
[Description]

Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism.
[Chemical Properties]

Piperazine citrate is a white, crystalline powder, with not more than a slight odor. It is soluble in water, and insoluble in alcohol and in ether.
[Uses]

Piperazine Citrate is an anthelmintic agent used in the treatment of parasitic infections. Also used in the reduction of blood pressure.
[Indications]

Used as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.
[Brand name]

Antepar (GlaxoSmithKline); Bryrel (Sanofi Aventis).
[Flammability and Explosibility]

Notclassified
[Mechanism of action]

Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.
[Pharmacokinetics]

Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.
Spectrum DetailBack Directory
[Spectrum Detail]

Piperazine citrate(144-29-6)MS
Piperazine citrate(144-29-6)1HNMR
Piperazine citrate(144-29-6)13CNMR
Piperazine citrate(144-29-6)IR1
Piperazine citrate(144-29-6)IR2
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

144-29-6(sigmaaldrich)
[TCI AMERICA]

Piperazine Citrate  Hydrate,>98.0%(T)(144-29-6)
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