| Identification | Back Directory | [Name]
FLAVIN ADENINE DINUCLEOTIDE | [CAS]
146-14-5 | [Synonyms]
Fademin
Flavinin
flavinat
flavitan
Wakadenin
NSC 112207
Flavine Adenine
5'-ester with adenosine
flavinadenindinucleotide
adenine-flavindinucleotide
adenine-flavinedinucleotide
FLAVIN ADENINE DINUCLEOTIDE
flavineadenosinediphosphate
Flavine-adenine dinucleotide
adenine-riboflavindinuceotide
flavin adenosine dinucleotide
adenine-riboflavindinucleotide
riboflavin-adeninedinucleotide
riboflavine-adeninedinucleotide
Flavin adenine dinucleotide ,95%
Flavine-adenine dinucleotide,96%
Adenine-riboflavine dinucleotide
isoalloxazine-adeninedinucleotide
flavinadeninedinucleotidedisodium
Riboflavin 5'-adenosine diphosphate
Riboflavine 5'-adenosine diphosphate
DISODIUM FLAVINE ADENINE DINUCLEOTIDE
FLAVIN ADENINE DINUCLEOTIDE 2NA (FAD)
Riboflavin 5'-(trihydrogen diphosphate)
Riboflavin5'-(trihydrogen diphosphate), P'®
FLAVINE ADENINE DINUCLEOTIDE SODIUM SALT extrapure
Riboflavine, 5'-ester with adenosine 5'-diphosphate (8CI)
flavineadeninedinucleotide,disodiumflavineadeninedinucleotide
riboflavin5’-(trihydrogendiphosphate),5’-5’-esterwithadenosine
Riboflavin 5-(trihydrogen diphosphate), P?5-ester with adenosine
adenosine5’-(trihydrogenpyrophosphate),5’-5’-esterwithriboflavine
riboflavin5’-(trihydrogendiphosphate),5’.fwdarw.5’-esterwithadenosine
Adenosine 5'-(trihydrogen pyrophosphate), 5'→5'-ester with riboflavine (8CI) | [EINECS(EC#)]
282-733-8 | [Molecular Formula]
C27H33N9O15P2 | [MDL Number]
MFCD00041835 | [MOL File]
146-14-5.mol | [Molecular Weight]
785.55 |
| Chemical Properties | Back Directory | [Definition]
An adenine
nucleotide containing two phosphate groups esterified to the sugar moiety at the 5′-position. | [Appearance]
solid | [density ]
2.08±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Methanol (Slightly, Heated), Water (Slightly) | [form ]
powder
| [pka]
1.13±0.50(Predicted) | [color ]
orange
| [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Merck ]
4091 | [Cosmetics Ingredients Functions]
VISCOSITY CONTROLLING | [InChIKey]
VWWQXMAJTJZDQX-ZGGJIJKNNA-N | [CAS DataBase Reference]
146-14-5 | [EPA Substance Registry System]
Riboflavin 5'-(trihydrogen diphosphate), P'.fwdarw.5'-ester with adenosine (146-14-5) |
| Hazard Information | Back Directory | [Chemical Properties]
solid | [Uses]
Labelled Flavine Adenine
xidase. Riboflavin kinase tumor necrosis factor receptor 1 NADPH oxidase | [Uses]
The prosthetic group of certain flavoproteins including D-amino acid oxidase, glucose oxidase, glycine oxidase, fumaric hydrogenase, histaminase, and xanthine oxidase. Riboflavin kinase tumor necrosis factor receptor 1 NADPH oxidase | [Description]
Flavin adenine dinucleotide (FAD) is a cofactor for cytochrome-b5 reductase, the enzyme that maintains hemoglobin in its functional reduced state, and for glutathione reductase. This enzyme also protects erythrocytes from oxidative damage. FAD is a redox cofactor of several essential reactions in metabolism. This cofactor exists in two redox states, with FAD and FADH2 being the oxidized and reduced forms, respectively. FAD is formed of a riboflavin moiety (vitamin B2) coupled to a phosphate group of an ADP molecule. The reaction starts with the conversion of riboflavin into flavin mononucleotide catalyzed by riboflavin kinase. Flavin mononucleotide is subsequently transformed into FAD by adding an AMP moiety from ATP catalyzed by FAD-synthase. Therefore, FAD availability is tightly dependent on vitamin B2 and energy metabolism[1].
| [References]
[1] Schnekenburger, M. and M. Diederich. “Nutritional Epigenetic Regulators in the Field of Cancer: New Avenues for Chemopreventive Approaches.”Epigenetic Cancer Therapy (2015): 393-425. | [storage]
Store at -20°C,protect from light | [Purification Methods]
Small quantities of FAD are purified by paper chromatography using tert-butyl alcohol/water, cutting out the main spot and eluting with water. Larger amounts can be precipitated from water as the uranyl complex by adding a slight excess of uranyl acetate to a solution at pH 6.0, dropwise and with gentle stirring. The solution is set aside overnight in the cold, and the precipitate is centrifuged off, washed with small portions of cold EtOH, then with cold peroxide-free diethyl ether. It is dried in the dark under vacuum over P2O5 at 50-60o. The uranyl complex is suspended in water, and, after adding sufficient 0.01M NaOH to adjust the pH to 7, the precipitate of uranyl hydroxide is removed by centrifugation [Huennekens & Felton Methods Enzymol 3 954 1957]. It can also be crystallised from water. It should be kept in the dark. More recently it was purified by elution from a DEAE-cellulose (Whatman DE 23) column with 0.1M phosphate buffer pH 7, and the purity was checked by TLC. [Holt & Cotton, J Am Chem Soc 109 1841 1987, Beilstein 26 III/IV 3632.] |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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