| Identification | Back Directory | [Name]
PAPA NONOATE | [CAS]
146672-58-4 | [Synonyms]
NOC-15
PAPA/NO
PAPA NONATE
PAPA NONOATE
NOC-15 NONOATE
PROPYLAMINE PROPYLAMINE NONOATE
3-[[nitroso(oxido)amino]-propylamino]propylazanium
1-HYDROXY-2-OXO-3-(3-AMINOPROPYL)-3-PROPYL-1-TRIAZENE
3-(2-hydroxy-2-nitroso-1-propylhydrazino)-1-propanamine
1-Propanamine, 3-(2-hydroxy-2-nitroso-1-propylhydrazinyl)-
3-(2-HYDROXY-2-NITROSO-1-PROPYLHYDRAZINO)-1-PROPANAMINE NONOATE
3-(2-Hydroxy-2-nitroso-1-propylhydrazino)-1-propanamine, NOC-15
(Z)-1-[N-(3-AMINOPROPYL)-N-)B-PROPYL)AMINO]DIAZIN-1-IUM-1,2-DIOLATE
(Z)-1-[N-(3-AMMONIOPROPYL)-N-(N-PROPYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE | [Molecular Formula]
C6H16N4O2 | [MDL Number]
MFCD00801020 | [MOL File]
146672-58-4.mol | [Molecular Weight]
176.22 |
| Chemical Properties | Back Directory | [Boiling point ]
277.2±42.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in Water or Ethanol. | [form ]
White to off-white solid. | [pka]
5.55±0.69(Predicted) | [color ]
Off-white | [Stability:]
Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Solutions are not stable and must be prepared immediately before use. |
| Hazard Information | Back Directory | [Description]
PAPA NONOate (146672-58-4) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of PAPA NONOate in 0.1 M phosphate buffer at pH 7.4 is 15 minutes at 37°C, or 77 minutes at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0. | [Uses]
PAPA NONOate is an NO donor which suppresses the caspase apoptotic cascade. | [Definition]
ChEBI: PAPA NONOate is an alkylamine. | [in vivo]
PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound[2]. | Animal Model: | Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound[2] | | Dosage: | 100 μM | | Administration: | Wounds received 100 μM PAPA NONOate in phosphate buffer | | Result: | Increased the wound healing rate in test group.
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| [References]
1) Keefer?et al. (1996),?‘NONOates’ (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol.,?268?281 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
|