ChemicalBook--->CAS DataBase List--->1474-78-8

1474-78-8

1474-78-8 Structure

1474-78-8 Structure
IdentificationMore
[Name]

Ethyl diethoxyphosphinylformate
[CAS]

1474-78-8
[Synonyms]

DIETHOXYPHOSPHINYLFORMIC ACID ETHYL ESTER
(ETHOXYCARBONYL)PHOSPHONIC ACID DIETHYL ESTER
ETHYL DIETHOXYPHOSPHINYLFORMATE
TRIETHYL PHOSPHONOFORMATE
Diethyl carbethoxyphosphonate
Diethyl ethoxycarbonylphosphonate
Ethyl diethoxyphosphinecarboxylate oxide
Formic acid, phosphono-, triethyl ester
phosphinecarboxylicacid,diethoxy-,ethylester,oxide
Triethyl carboxyphosphonate
Triethyl phosphonomethanoate
TRIETHYL PHOSPHONOFORMATE 98%
PhosphonoformicacidTriethylester
TRIETHYL PHOSPHONOFORMATE (ETHYL DIETHOXYPHOSPHINILFORMATE)
ethyl diethyl-phosphonoformate
ETHYL DIETHOXYPHOSPHINYLFORMATE (TRIETHYL PHOSPHONOFORMATE)
[EINECS(EC#)]

216-016-8
[Molecular Formula]

C7H15O5P
[MDL Number]

MFCD00009108
[Molecular Weight]

210.16
[MOL File]

1474-78-8.mol
Chemical PropertiesBack Directory
[Appearance]

Clear colorless to slightly yellow liquid
[Boiling point ]

135 °C12 mm Hg(lit.)
[density ]

1.11 g/mL at 25 °C(lit.)
[refractive index ]

n20/D 1.423(lit.)
[Fp ]

>230 °F
[storage temp. ]

Store below +30°C.
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

neat
[color ]

Colorless to Almost colorless
[Specific Gravity]

1.11
[BRN ]

1781949
[Stability:]

Moisture Sensitive
[InChI]

1S/C7H15O5P/c1-4-10-7(8)13(9,11-5-2)12-6-3/h4-6H2,1-3H3
[InChIKey]

NOJFJZZMRDSOLM-UHFFFAOYSA-N
[CAS DataBase Reference]

1474-78-8(CAS DataBase Reference)
[NIST Chemistry Reference]

Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide(1474-78-8)
[EPA Substance Registry System]

1474-78-8(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S24/25:Avoid contact with skin and eyes .
S36/37:Wear suitable protective clothing and gloves .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
[WGK Germany ]

3
[TSCA ]

Yes
[REACH Registrations]

Active
[HS Code ]

29319019
[Storage Class]

10 - Combustible liquids
Raw materials And Preparation ProductsBack Directory
[Preparation Products]

Foscarnet sodium-->Foscarnet Impurity A
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Ethyl diethoxyphosphinylformate(1474-78-8).msds
Hazard InformationBack Directory
[Chemical Properties]

Clear colorless to slightly yellow liquid
[Uses]

Diethyl (Ethoxycarbonyl)phosphonate is an impurity in the synthesis of Foscarnet (F727400), an inhibitor of viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.
[General Description]

for synthesis
[Purification Methods]

Dissolve it in Et2O, shake this with H2O (to remove any trace of NaCl impurity), dry (Na2SO4), evaporate and distil it using an efficient fractionating column. [Nylén Chem Ber 57 1035 1924, Reetz et al. J Am Chem Soc 77 3813 1955, Monson Advanced Organic Synthesis Academic Press p 89 1972, Beilstein 3 II 103.]
Spectrum DetailBack Directory
[Spectrum Detail]

Ethyl diethoxyphosphinylformate(1474-78-8)MS
Ethyl diethoxyphosphinylformate(1474-78-8)1HNMR
Ethyl diethoxyphosphinylformate(1474-78-8)13CNMR
Ethyl diethoxyphosphinylformate(1474-78-8)IR1
Well-known Reagent Company Product InformationBack Directory
[Alfa Aesar]

Ethyl diethoxyphosphinylformate, 98%(1474-78-8)
[Sigma Aldrich]

1474-78-8(sigmaaldrich)
[TCI AMERICA]

Ethyl Diethoxyphosphinylformate,>98.0%(GC)(1474-78-8)
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