| Identification | More | [Name]
Tripropyl orthoformate | [CAS]
621-76-1 | [Synonyms]
ORTHOFORMIC ACID TRI-N-PROPYL ESTER
ORTHOFORMIC ACID TRIPROPYL ESTER
ORTHOFORMIC TRIPROPYL ESTER
TNPOF
TRI-N-PROPYL ORTHOFORMATE
TRIPROPOXYMETHANE
TRIPROPYL ORTHOFORMATE
1-(Dipropoxymethoxy)propane
Propane, 1,1',1''-[methylidynetris(oxy)]tris-
n-Propyl orthoformate
1,1',1''-[methylidynetris(oxy)]trispropane
1,1′,1′′-[Methylidyntris(oxy)]trispropan | [EINECS(EC#)]
210-704-1 | [Molecular Formula]
C10H22O3 | [MDL Number]
MFCD00015214 | [Molecular Weight]
190.28 | [MOL File]
621-76-1.mol |
| Questions And Answer | Back Directory | [Preparation]
The process conditions for synthesizing tripropyl orthoformate from hydrogen cyanide, hydrochloric acid gas, and n-propanol are as follows: In the presence of H3 solvent, the catalyst dosage is 0.5%, the ratio of hydrogen cyanide to hydrochloric acid gas is 1:1.15, the reaction temperature is 5–15℃, the alcoholysis temperature is 40–50℃, the alcoholysis reaction time is 4 h, and the yield reaches 94%. This reaction has the advantages of mild conditions, easy operation, easy control, and high yield, making it an ideal method for synthesizing tripropyl orthoformate with significant industrial value. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
1993 | [WGK Germany ]
1
| [F ]
10-21 | [TSCA ]
Yes | [REACH Registrations]
Active | [HS Code ]
29159000 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless liquid | [Uses]
Tripropyl orthoformate was used as alcohol donor to investigate the activity and enantioselectivity of Novozym 435 in the esterification of rac-fenoprofen in methylcyclohexane. It may be used as a drying agent during the synthesis of squaraine derivatives. | [Uses]
Tripropoxymethane can be used in the lipase-?catalyzed esterification aimed at the kinetic resolution of racemic acids, circumventing the adverse effects of the water formed in the course of the reaction. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 77, p. 3801, 1955 DOI: 10.1021/ja01619a036 | [General Description]
Gas phase reactions of the rare earth metal cations with tripropyl orthoformate were studied by Fourier transform ion cyclotron resonance mass spectrometry. |
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J & K SCIENTIFIC LTD.
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Alfa Aesar
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Energy Chemical
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Maya High Purity Chemicals
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Sigma-Aldrich
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