| Identification | Back Directory | [Name]
4H-Oxazolo[4,5-d]azepin-2-amine, 6-ethyl-5,6,7,8-tetrahydro-, hydrochloride (1:1) | [CAS]
147663-20-5 | [Synonyms]
Azepexole hydrochloride, 10 mM in DMSO
4H-Oxazolo[4,5-d]azepin-2-amine, 6-ethyl-5,6,7,8-tetrahydro-, hydrochloride (1:1) | [Molecular Formula]
C9H16ClN3O | [MOL File]
147663-20-5.mol | [Molecular Weight]
217.7 |
| Hazard Information | Back Directory | [Uses]
Azepexole hydrochloride (B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride) is a selective agonist for α 2-adrenoceptor, with pKi of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions with IC50 of 78.72 nM. Azepexole hydrochloride exhibits antitussive and analgesic efficacy[1][2]. | [References]
[1] Altamirano-Espinoza AH, et al. Specific role of α2A - and α2B -, but not α2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats. Basic Clin Pharmacol Toxicol. 2015;117(1):31-38. DOI:10.1111/bcpt.12354
[2] Capey S. Azepexole[J]. 2007.Pharm: The Comprehensive Pharmacology Reference. |
|
|