| Identification | More | [Name]
2-Methoxy-5-fluorouracil | [CAS]
1480-96-2 | [Synonyms]
2-METHOXY-5-FLUORO-2,3-DIHYDROPYRIMIDIN-4(1H)-ONE
5-FLUORO-2-METHOXY-3H-PYRIMIDIN-4-ONE
5-FLUORO-2-METHOXY-4(1H)PYRIMIDINONE
5-FLUORO-2-METHOXY-4-PYRIMIDINONE
5-FLUORO-2-METHOXYURACIL
5-FLUORO-2-METHOXY-4(1H)PYRIMIDINONE, 9&
5-Fluoro-2-methoxy-pyrimidin-4-ol
4(1H)-Pyrimidinone, 5-fluoro-2-methoxy-(9CI)
2-Methoxyl-5-fluorouracil
2-O-METHYL-5-FLUOROURACIL
5-Fluoro-2-methoxy-4(3H)-pyrimidinone | [EINECS(EC#)]
473-810-9 | [Molecular Formula]
C5H5FN2O2 | [MDL Number]
MFCD03265437 | [Molecular Weight]
144.1 | [MOL File]
1480-96-2.mol |
| Questions And Answer | Back Directory | [Synthesis]
Acetamide and methyl chloroacetate were used as raw materials to prepare the key intermediate methyl fluoroacetate. The product was then cyclized with O-methylisourea sulfate under sodium methoxide catalysis to yield the target compound 2-methoxy-5-fluorouracil. The synthetic reaction formula is shown in the figure below:  |
| Chemical Properties | Back Directory | [Melting point ]
204-208 °C(lit.) | [Boiling point ]
225.1℃[at 101 325 Pa] | [density ]
1.44±0.1 g/cm3(Predicted) | [vapor pressure ]
0.001Pa at 25℃ | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
soluble in DMSO, Methanol | [form ]
Solid | [pka]
6.34±0.50(Predicted) | [color ]
Off-White | [Water Solubility ]
5.49g/L at 20℃ | [InChI]
InChI=1S/C5H5FN2O2/c1-10-5-7-2-3(6)4(9)8-5/h2H,1H3,(H,7,8,9) | [InChIKey]
VMIFBCPINLZNNI-UHFFFAOYSA-N | [SMILES]
C1(OC)=NC=C(F)C(=O)N1 | [LogP]
-0.226 at 25℃ | [CAS DataBase Reference]
1480-96-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [REACH Registrations]
Inactive | [HS Code ]
29335990 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
5-Fluoro-4-hydroxy-2-methoxypyrimidine (cas# 1480-96-2) is a compound useful in organic synthesis. | [Flammability and Explosibility]
Notclassified |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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