| Identification | More | [Name]
2,4-Difluoro-5-chloronitrobenzene | [CAS]
1481-68-1 | [Synonyms]
2,4-DIFLUORO-5-CHLORO NITROBENZENE
5-CHLORO-2,4-DIFLUORONITROBENZENE
1-chloro-2,4-difluoro-5-nitrobenzene
5-Chloro-2,4-difluoronitrobenz | [EINECS(EC#)]
216-040-9 | [Molecular Formula]
C6H2ClF2NO2 | [MDL Number]
MFCD06658249 | [Molecular Weight]
193.54 | [MOL File]
1481-68-1.mol |
| Chemical Properties | Back Directory | [Boiling point ]
105 °C(Press: 15 Torr) | [density ]
1.591±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [Appearance]
Light yellow to brown Liquid | [InChI]
InChI=1S/C6H2ClF2NO2/c7-3-1-6(10(11)12)5(9)2-4(3)8/h1-2H | [InChIKey]
UIOYEIHBWQTVJC-UHFFFAOYSA-N | [SMILES]
C1(Cl)=CC([N+]([O-])=O)=C(F)C=C1F | [CAS DataBase Reference]
1481-68-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
2,4-Difluoro-5-chloronitrobenzene can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly in laboratory research and development processes and chemical production processes. | [Synthesis]
Toluene was distilled from the mixture of potassium fluoride (38.2 g, 657 mmol), cetrimide (5.94 g, 17.6 mmol), DMF (250 mL), and dry toluene (100 mL) to remove traces of moisture. 2,4,5- Trichloronitrobenzene (7) (50.0 g, 220 mmol) was added and heated at 125 ??C for 12 h under N2. The reaction mixture was cooled, diluted with water, and extracted with ethyl acetate. The organic layer was washed with brine, dried (Na2SO4), and evaporated to give a residue, which was distilled under vacuo to provide 9 (23.5 g, 55%). bp = 83 ??C at 0.5 Torr, lit. bp) 85 ??C at 0.5 Torr; 1H NMR (CDCl3, 200 MHz) |? 7.18 (t, 1 H, J = 9.2 Hz), 8.24 (t, 1 H, J = 7.4 Hz). | [References]
[1] Synthetic Communications, 1994, vol. 24, # 4, p. 529 - 532
[2] Patent: US5576455, 1996, A
[3] Patent: US5294742, 1994, A
[4] Organic Process Research and Development, 2003, vol. 7, # 3, p. 309 - 312 |
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Tocopharm Co., Ltd.
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| Telephone: |
+86-021-69895597 13776836200 +86-13776836200 |
| Website: |
http://www.tocopharm.com/ |
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