| Identification | More | [Name]
2,6-Dichloro-3-iodopyridine | [CAS]
148493-37-2 | [Synonyms]
2,6-DICHLORO-3-IODOPYRIDINE
2-Dichloro-3-Iodopyridine | [Molecular Formula]
C5H2Cl2IN | [MDL Number]
MFCD03094686 | [Molecular Weight]
273.89 | [MOL File]
148493-37-2.mol |
| Questions And Answer | Back Directory | [Synthesis]
At -78°C, diisopropylamine (3.50 mL, 2.50 g, 25.0 mmol) and 2,6-dichloropyridine (3.70 g, 25.0 mmol) were added sequentially to a mixed solution of n-BuLi (10.0 mL, 25.0 mmol, 2.50 M in hexane) and THF (40 mL). After stirring at -78°C for 2 hours, a THF (25 mL) solution of iodine (7.40 g, 29.0 mmol) was added, and the reaction mixture was allowed to reach room temperature. After 30 minutes, H2O (100 mL) was added to the mixture. The aqueous layer was extracted with Et₂O (3 x 75 mL). The combined organic extracts were washed with saturated NH₄Cl aqueous solution (75 mL) and saturated Na₂S₂O₅ aqueous solution (25 mL). The organic extract was dried with Na₂SO₄ and concentrated under vacuum to obtain 2,6-dichloro-3-iodopyridine. |
| Chemical Properties | Back Directory | [Appearance]
Light yellow powder | [Melting point ]
74-79 °C | [Boiling point ]
294.8±35.0 °C(Predicted) | [density ]
2.129±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
Powder | [pka]
-3.87±0.10(Predicted) | [color ]
White to brown | [Water Solubility ]
Slightly soluble in water. | [Sensitive ]
Light Sensitive | [InChI]
1S/C5H2Cl2IN/c6-4-2-1-3(8)5(7)9-4/h1-2H | [InChIKey]
DPCQIHCGMIPSQV-UHFFFAOYSA-N | [SMILES]
Clc1ccc(I)c(Cl)n1 | [CAS DataBase Reference]
148493-37-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
22-37/38-41 | [Safety Statements ]
26-36 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
6.1 | [HazardClass ]
IRRITANT | [PackingGroup ]
III | [HS Code ]
2933399990 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
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