| Identification | Back Directory | [Name]
AG 825 | [CAS]
149092-50-2 | [Synonyms]
AG 825
Zinc02572484
TYRPHOSTIN C15
AG 825 USP/EP/BP
TYRPHOSTIN AG 825
AG 825 (Tyrphostin AG 825)
AG 825 - CAS 149092-50-2 - Calbiochem
4-HYDROXY-3-METHOXY-5-(BENZOTHIAZOLYLTHIOMETHYL)BENZYLIDENECYANOACETAMIDE
5-[(BENZTHIAZOL-2-YL)THIOMETHYL]-4-HYDROXY-3-METHOXYBENZYLIDENECYANOACETAMIDE
5-[(BENZOTHIAZOL-2-YL)THIOMETHYL]-4-HYDROXY-3-METHOXYBENZYL-IDENECYANOACETAMIDE
3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-
2-Propenamide
2-Propenamide, 3-[3-[(2-benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-
(E)-3-[3-[(2-BENZOTHIAZOLYTHIO)METHYL]-4-HYDROXY-5-METHOXYPHENYL]-2-CYANO-2-PROPENAMIDE
Tyrphostin C15, 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide | [Molecular Formula]
C19H15N3O3S2 | [MDL Number]
MFCD01074971 | [MOL File]
149092-50-2.mol | [Molecular Weight]
397.47 |
| Hazard Information | Back Directory | [Uses]
A selective ErbB2 inhibitor | [Uses]
AG 825 is a selective ErbB2 (Neu) inhibitor and apoptosis inducer. | [Definition]
ChEBI: An organic sulfide that consists of 1,3-benzothiazole-2-thiol in which the hydrogen attached to the sulfur atom is replaced by a 5-[(1E)-3-amino-2-cyano-3-oxoprop-1-en-1-yl]-2-hydroxy-3-methoxybenzyl group. It acts as an epidermal growth
factor receptor antagonist. | [Biological Activity]
Selective ErbB2 inhibitor (IC 50 values are 0.15 and 19 mM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells. | [in vivo]
AG-825 (20 mg/kg, i.p.) decreases peritoneal inflammation in Zymosan (HY-159069)-treated mice, and increases lung neutrophil apoptosis and macrophage efferocytosis in a murine acute lung injury model[4].
AG-825 (1 mg/kg, min-osmotic pump, 14 days) causes cardiac dilation and selective increase in β1AR density in mice[7].
| Animal Model: | Murine model of LPS induced acute lung inflammation[4] | | Dosage: | 20 mg/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Had no effect on percentage of, or absolute number of neutrophils or macrophages.
Increased the percentage of neutrophil apoptosis.
Elevated macrophage efferocytosis.
|
| Animal Model: | Murine model of Zymosan (HY-159069)-induced peritonitis[4] | | Dosage: | 20 mg/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Did not induce leukopenia.
Showed fewer inflammatory cells in peritoneal lavage.
Reduced the neutrophil chemoattractant and proinflammatory cytokine, KC.
Reduced IgM.
|
| [IC 50]
ErbB2: 0.35 μM (IC50); EGFR: 19 μM (IC50) | [storage]
Store at -20°C |
|
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
Synchem OHG
|
| Tel: |
+49 5662 408730 |
| Website: |
www.synchem.de |
|