| Identification | Back Directory | [Name]
Solvent Red 43 | [CAS]
15086-94-9 | [Synonyms]
EOSINE
RED 21
AKA223
EOSIN Y
EOSIN G
EOSINE Y
EOSINE B
EOSINE J
S NO 881
D&CRED21
ihydroxy-
redno.223
EOSIN 225
bromeosin
EOSIN Y TS
eosineacid
Bromoeosin
D&CREDNO.21
japanred223
EOSIN STAIN
CI NO 45380
’-dihydroxy-
BROMO ACID J
dandcredno.21
eosinyfreeacid
japanredno.223
Eosin Y powder
Solvent Red 43
BRONZE BROMO ES
EOSIN Y NA-SALT
BROMOFLUORESCEIN
EOSIN, INSOLUBLE
C.I.SolventRed43
CI NO 45380/52015
D AND C RED NO 22
EOSIN-HEMATOXYLIN
EOSIN YELLOWISH Y
Eosin Y (alcohol)
EOSIN DISODIUM FRP
EOSIN Y (YELLOWISH)
EosinYellow,freecid
Eosin Y alcohol solu
EOSIN METHYLENE BLUE
EOSIN Y, SODIUM SALT
EOSIN Y DISODIUM SALT
LABOTEST-BB LT00159820
TETRABROMO-FLUORESCEIN
EOSIN Y, SPIRIT SOLUBLE
HIDACID EOSINE SODA SALT
Eosin Y, analytical grade
BROMO ACID J TS, XL, OR XX
TETRABROMO (R) FLUORESCEIN
SODIUM TETRABROMOFLUORESCEIN
Solvent red 43 (C.I. 45380:2)
Eosin Y,90-95%,pure,free acid
EOSIN YELLOWISH WATER-SOLUBLE
Eosin Y, 1% Solution in Water
EOSIN, SODIUM SALT (YELLOWISH)
eosin yellowish, spirit soluble
2'4',5',7'-TETRABROMOFLUORESCEIN
2’,4’,5’,7’-tetrabromo-fluorescei
Eosin Y free acid alcohol soluble
TETRABROMOFLUORESCEIN SODIUM SALT
2,4,5,7-Tetrabromo-3,6-fluorandiol
EOSIN Y, SPIRIT SOLUBLE, HIGH PURITY
HEMATOXYLIN-EOSIN ACCORDING TO EHRLICH
2,4,5,7-TETRABROMOFLUORESCEIN, SODIUM SALT
2',4',5',7'-TETRABROMOFLUORESCEIN SODIUM SALT
EOSIN Y, FREE ACID (DYE CONTENT: 99%) HIGH PURITY
Bromofluorescein, 2',4',5',7'-Tetrabromofluorescein
EOSIN Y C.I. NO. 45380 ALCOHOL SOLUBLE BIOGICAL STAIN
2-(3,6-dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid
3,6-Dihydroxy-2,4,5,7-tetrabromospiro(xanthene-9,3'-phthalide)
spiro(isobenzofuran-1(3h),9’-(9h)-xanthen)-3-one,2’,4’,5’,7’-tetrabromo-3’,6
Spiroisobenzofuran-1(3H),9-9Hxanthen-3-one, 2,4,5,7-tetrabromo-3,6-dihydroxy-
2',4',5',7'-Tetrabromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one
9’-[9H]xanthen]-3-one,2’,4’,5’,7’-tetrabromo-3’,6’-dihydroxy-Spiro[isobenzofuran-1(3H)
2μ,4μ,5μ,7μ-Tetrabromofluorescein, Acid Red 87, Bromo acid J. TS, XL, or XX, Bromofluorescein, Bronze Bromo ES, Eosin yellowish, Solvent red 43 | [EINECS(EC#)]
241-409-6 | [Molecular Formula]
C20H8Br4O5 | [MDL Number]
MFCD00005040 | [MOL File]
15086-94-9.mol | [Molecular Weight]
647.89 |
| Chemical Properties | Back Directory | [Appearance]
orange-brown powder | [Melting point ]
300 °C
| [Boiling point ]
640.3±55.0 °C(Predicted) | [density ]
1.02 g/mL at 20 °C
| [refractive index ]
1.5000 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
H2O: 0.1 g/mL, dark red
| [Colour Index ]
45380:2 | [form ]
Liquid | [pka]
6.97±0.20(Predicted) | [color ]
White to Light yellow to Red | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [λmax]
524 nm | [Henry's Law Constant]
4.4×1012 mol/(m3Pa) at 25℃, Zhang et al. (2010) | [Major Application]
diagnostic assay manufacturing
hematology
histology | [Cosmetics Ingredients Functions]
COLORANT | [InChI]
1S/C20H8Br4O5/c21-11-5-9-17(13(23)15(11)25)28-18-10(6-12(22)16(26)14(18)24)20(9)8-4-2-1-3-7(8)19(27)29-20/h1-6,25-26H | [InChIKey]
DBZJJPROPLPMSN-UHFFFAOYSA-N | [SMILES]
Oc1c(Br)cc2c(Oc3c(Br)c(O)c(Br)cc3C24OC(=O)c5ccccc45)c1Br | [CAS DataBase Reference]
15086-94-9 | [IARC]
3 (Vol. 15, Sup 7) 1987 | [EPA Substance Registry System]
Spiro[isobenzofuran- 1(3H),9'-[9H]xanthen]- 3-one, 2',4',5',7'- tetrabromo-3',6'- dihydroxy-(15086-94-9) |
| Hazard Information | Back Directory | [Chemical Properties]
orange-brown powder | [Uses]
Eosin Acid C.I. No. 45380 (CAS# 15086-94-9) is a photo-senseitive organic catalyst and has been used in the photocatalytic, diastereoselective additions of 1-sulfoximidoyl-1,2-benziodoxoles to styrenes, and in the stereoselective synthesis of 2-deoxyglycosides from glycals. Dyes and metabolites. | [Definition]
ChEBI:Bromoeosin is an organobromine compound. It is functionally related to a fluorescein (lactone form). | [Preparation]
Fluorescein (C.I. Acid Yellow 73, C.I. 45350) in water or ethanol solution bromide into four bromine derivatives, And made into a free acid form.. | [Biological Activity]
Eosin Y is a xanthene dye and is used for the differential staining of connective tissue and cytoplasm. In histopathologyit is applied as a counterstain after hematoxylin and before methylene blue. It is also used as a background stainthereby giving contrast to the nuclear stains. | [Synthesis]
The general procedure for the synthesis of 2',4',5',7'-tetrabromo-3',6'-dihydroxy-3H-spiro[isobenzofuran-1,9'-xanthene]-3-one from 3',6'-dihydroxy-3H-spiro[isobenzofuran-1,9'-xanthene] is as follows: fluorescein in the form of the lactone (1 eq.), NaBr (16 eq.), and Oxone? ( 6 equiv, 2KHSO5-KHSO4-K2SO4) were mixed and ground in an agate mortar until uniformly fine. The resulting solid mixture was reacted in an oven at 200 °C for 12 h. Upon completion of the reaction, the target product tetrabromofluorescein (4Br-F) was obtained in near 100% yield in the commercial disodium salt form known as eosin Y. The reaction mixture was diluted with water and the product was extracted with ethyl acetate. The product was characterized by mass spectrometry (ESI-MS) and spectroscopic techniques (1H-NMR and 13C-NMR). The specific data were as follows: ESI-MS (+) of 4Br-F: m/z 670.4 [M + H]+; 1H NMR (CH3OD): δ 7.04 ppm (s, 1H and 8H), 7.23 (d, J = 8.0 Hz, 3H), 7.72 (ddd, J = 8.0, 8.0, 1.2 Hz, 5H), 7.79 (ddd, J = 8.0, 8.0, 1.2 Hz, 4H), 8.09 ppm (d, J = 8.0 Hz, 6H). | [storage]
4°C, protect from light, stored under nitrogen | [Properties and Applications]
brilliant yellow red. Soluble in water and ethanol for blue light red, with yellow green fluorescence. In concentrated sulfuric acid to yellow, dilution after yellow red precipitation. | [References]
[1] Patent: US2008/61289, 2008, A1. Location in patent: Page/Page column 6-7
[2] Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 5, p. 216
[3] Journal of the American Chemical Society, 1927, vol. 49, p. 1278
[4] Justus Liebigs Annalen der Chemie, 1876, vol. 183, p. 31
[5] Justus Liebigs Annalen der Chemie, 1910, vol. 372, p. 109 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Energy Chemical
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400-0056266 |
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Maya High Purity Chemicals
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Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277 |
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