| Identification | Back Directory | [Name]
4'-Hydroxy-2,4-dimethoxychalcone | [CAS]
151135-64-7 | [Synonyms]
4-O-Methylechinatin
4'-Hydroxy-2,4-dimethoxychalcone
2-Propen-1-one, 3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)- | [Molecular Formula]
C17H16O4 | [MOL File]
151135-64-7.mol | [Molecular Weight]
284.31 |
| Hazard Information | Back Directory | [Uses]
4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity[1][2]. | [in vivo]
4'-Hydroxy-2,4-dimethoxychalcone (compound 2; oral; 160 mg/kg) has a T1/2 of 1.94 hours, a Cmax of 158 ng/mL and an AUC of 384 ng?h/mL in four- to five-week-old ICR mice[1]. | [IC 50]
Plasmodium | [References]
[1] Clare E Gutteridge, et al. In vitro biotransformation, in vivo efficacy and pharmacokinetics of antimalarial chalcones. Pharmacology. 2011;87(1-2):96-104. DOI:10.1159/000322532
[2] Qing-An Zheng, et al. Flavonoids from the Resin of Dracaena cochinchinensis. Helvetica Chimica Acta, 87(5), 1167–1171. |
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