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151135-64-7

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151135-64-7 Structure

151135-64-7 Structure
IdentificationBack Directory
[Name]

4'-Hydroxy-2,4-dimethoxychalcone
[CAS]

151135-64-7
[Synonyms]

4-O-Methylechinatin
4'-Hydroxy-2,4-dimethoxychalcone
2-Propen-1-one, 3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)-
[Molecular Formula]

C17H16O4
[MOL File]

151135-64-7.mol
[Molecular Weight]

284.31
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity[1][2].
[in vivo]

4'-Hydroxy-2,4-dimethoxychalcone (compound 2; oral; 160 mg/kg) has a T1/2 of 1.94 hours, a Cmax of 158 ng/mL and an AUC of 384 ng?h/mL in four- to five-week-old ICR mice[1].

[IC 50]

Plasmodium
[References]

[1] Clare E Gutteridge, et al. In vitro biotransformation, in vivo efficacy and pharmacokinetics of antimalarial chalcones. Pharmacology. 2011;87(1-2):96-104. DOI:10.1159/000322532
[2] Qing-An Zheng, et al. Flavonoids from the Resin of Dracaena cochinchinensis. Helvetica Chimica Acta, 87(5), 1167–1171.
Spectrum DetailBack Directory
[Spectrum Detail]

4'-Hydroxy-2,4-dimethoxychalcone(151135-64-7)1HNMR
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