ChemicalBook--->CAS DataBase List--->20702-77-6

20702-77-6

20702-77-6 Structure

20702-77-6 Structure
IdentificationMore
[Name]

Neosperidin dihydrochalcone
[CAS]

20702-77-6
[Synonyms]

1-[4-[[2-O-(6-DEOXY-ALPHA-L-MANNOPYRANOSYL)-BETA-D-GLUCOPYRANOSYL]OXY]-2,6-DIHYDROXYPHENYL]-3-(3-HYDROXY-4-METHOXYPHENYL)-1-PROPANONE
E-959
FEMA 3811
NEOHESPERIDIN DIHYDROCHALCONE
NEOHESPERIDIN DIHYDROCHALCONE HYDRATE
NEOHESPERIDINE DC
NEOHESPERIDINE DIHYDROCHALCONE
NEOHESPERIDINE DIHYDROCHALCONE HYDRATE
neosperidin dihydrochalcone
beta-d--(6-deoxy-alpha-l-mannopyranosyl)
glucopyranoside,3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl-2-o
nci-c60764
neohesperidin dihydrochalcone from*citrus fruit
Neosperidin Dihydro halcone
NEOHESPERIDIN DIHYDROCHALCONE 85+%
Neohesperidine hydrate
1-Propanone, 1-4-2-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyloxy-2,6-dihydroxyphenyl-3-(3-hydroxy-4-methoxyphenyl)-
1-(4-((2-o-[6-deoxy-α-l-mannopyranosyl]-β-d-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone
Neohesperidin Dihydrochalcone ( NHDC )
BETA-NEOHESPERIDINDIHYDROCHALCONE
[EINECS(EC#)]

243-978-6
[Molecular Formula]

C28H38O16
[MDL Number]

MFCD03840557
[Molecular Weight]

630.59
[MOL File]

20702-77-6.mol
Chemical PropertiesBack Directory
[Melting point ]

156-158 °C(lit.)
[Boiling point ]

927.1±65.0 °C(Predicted)
[density ]

1.61±0.1 g/cm3(Predicted)
[vapor pressure ]

0Pa at 20℃
[FEMA ]

3811
[storage temp. ]

−20°C
[solubility ]

Practically insoluble in water, freely soluble in dimethyl sulfoxide, soluble in methanol, practically insoluble in methylene chloride.
[form ]

crystalline
[pka]

6.85±0.40(Predicted)
[color ]

light yellow
[Odor]

at 100.00 %. bland odor
[Odor Type]

odorless
[Water Solubility ]

Insoluble
[Merck ]

6452
[Stability:]

Hygroscopic
[InChIKey]

ITVGXXMINPYUHD-CUVHLRMHSA-N
[LogP]

0.67 at 20℃
[CAS DataBase Reference]

20702-77-6(CAS DataBase Reference)
[EPA Substance Registry System]

20702-77-6(EPA Substance)
Safety DataBack Directory
[WGK Germany ]

3
[RTECS ]

LZ5785000
[HS Code ]

29389090
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Hesperetin-->Naringin-->Neohesperidin
Hazard InformationBack Directory
[General Description]

Off-white crystals or powder. Insoluble in water.
[Reactivity Profile]

NEOHESPERIDIN DIHYDROCHALCONE(20702-77-6) is a ether-alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert alcohols to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
[Air & Water Reactions]

Insoluble in water.
[Fire Hazard]

The flash point of this material has not been determined, but NEOHESPERIDIN DIHYDROCHALCONE is probably combustible.
[Chemical Properties]

Crystal
[Chemical Properties]

Neohesperidin dihydrochalcone occurs as a white or yellowishwhite powder with an intensely sweet taste.
[Uses]

Preparation from Naringen, a flavanone glycoside occurring naturally in grapefruit. It is used as sweetening agent, especially in chewing gum and dentifrices.
[Uses]

Sweetening agent, especially in chewing gum and dentifrices.
[Definition]

ChEBI: A member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage. It is found in sweet orange.
[Production Methods]

Neohesperidin dihydrochalcone is synthesized commercially from either of the bitter-flavanones neohesperidin or naringin by catalytic hydrogenation under alkaline conditions in a process first described in the 1960s, in which neohesperidin is purified by recrystallization from water solutions.Neohesperidin dihydrochalcone is obtained by the alkaline hydrogenation of neohesperidin.
[Flammability and Explosibility]

Notclassified
[Pharmaceutical Applications]

Neohesperidin dihydrochalcone is a synthetic intense sweetening agent approximately 1500–1800 times sweeter than sucrose and 20 times sweeter than saccharin. Structurally it is an analogue of neohesperidin, a flavanone that occurs naturally in Seville oranges (Citrus aurantium). Neohesperidin dihydrochalcone is used in pharmaceutical and food applications as a sweetening agent and flavor enhancer. The sweetness profile is characterized by a lingering sweet/menthol-like aftertaste.The typical level used in foods is 1–5 ppm although much higher levels may be used in certain applications such as chewing gum. Synergistic effects occur with other intense and bulk sweeteners such as acesulfame K, aspartame, polyols, and saccharin.
In pharmaceutical applications, neohesperidin dihydrochalcone is useful in masking the unpleasant bitter taste of a number of drugs such as antacids, antibiotics, and vitamins. In antacid preparations, levels of 10–30 ppm result in improved palatability.
[Safety]

Neohesperidin dihydrochalcone is accepted for use in food products either as a sweetener or flavor modifier in a number of areas including Europe, USA, Australia, New Zealand, and several countries in Africa and Asia. It is also used in a number of oral pharmaceutical formulations.
Animal toxicity studies suggest that neohesperidin dihydrochalcone is a nontoxic, nonteratogenic, and noncarcinogenic material at the levels used in foods and pharmaceuticals.In Europe, an acceptable daily intake of 0–5 mg/kg body-weight has been established.
[storage]

Neohesperidin dihydrochalcone is stable for over three years when stored at room temperature.
Accelerated stability studies on aqueous solutions stored at 30–60°C and pH 1–7 for 140 days indicate that neohesperidin dihydrochalcone solutions are likely to be stable for 12 months at room temperature and pH 2–6.Solutions formulated with some or all of the water replaced by solvents with a lower dielectric constant are reported to have longer shelf-lives.
The bulk material should be stored in a cool, dry, place protected from light.
[Regulatory Status]

GRAS listed. Accepted for use as a food additive in Europe.
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

1-(4-((2-O-[6-Deoxy-alpha-L-mannopyranosyl]-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone(20702-77-6).msds
Spectrum DetailBack Directory
[Spectrum Detail]

Neosperidin dihydrochalcone(20702-77-6)MS
Neosperidin dihydrochalcone(20702-77-6)1HNMR
Neosperidin dihydrochalcone(20702-77-6)IR1
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

20702-77-6(sigmaaldrich)
[TCI AMERICA]

Neohesperidin Dihydrochalcone  Hydrate,>98.0%(T)(20702-77-6)
20702-77-6 suppliers list
Company Name: Shaanxi Haibo Biotechnology Co., Ltd
Tel: +86-02963020060 +86-18629295024 , +86-18629295024
Website: www.rozenbio.com/
Company Name: Hebei Mojin Biotechnology Co., Ltd
Tel: +86-13288715578 +86-13231137666 , +86-13231137666
Website: www.mojinchemical.com
Company Name: Hebei Yanxi Chemical Co., Ltd.
Tel: +8617531190177 , +8617531190177
Website: www.chemicalbook.com/manufacturer/hebei-yanxi-chemical-283/
Company Name: Henan Bao Enluo International TradeCo.,LTD
Tel: +86-17331933971 +86-17331933971 , +86-17331933971
Website: baoenluo.guidechem.com/
Company Name: Wuhan Haorong Biotechnology Co.,ltd
Tel: +8618565342920 , +8618565342920
Website:
Company Name: Shanghai Daken Advanced Materials Co.,Ltd
Tel: +86-371-66670886
Website: www.dakenam.com/
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512 , +86-19937530512
Website: https://www.tianfuchem.com/
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008657128800458; +8615858145714 , +8615858145714
Website: http://www.fandachem.com
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: +86-0551-65418679 +86-18949832763 , +86-18949832763
Website: http://www.tnjchem.com
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Website: www.chemicalbook.com/ShowSupplierProductsList30845/0.htm
Company Name: career henan chemical co
Tel: +86-0371-86658258
Website: https://www.coreychem.com/
Company Name: Chengdu GLP biotechnology Co Ltd
Tel: 028-87075086 13350802083 , 13350802083
Website: www. GLP-China.com
Company Name: Chengdu Biopurify Phytochemicals Ltd.
Tel: +8618080483897 , +8618080483897
Website: www.phytopurify.com
Company Name: Jinan Shengqi pharmaceutical Co,Ltd
Tel: 86+18663751872
Website: www.shengqipharm.com
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Website: www.hubeijusheng.com
Company Name: Jinan Finer Chemical Co., Ltd
Tel: +86-531-88989536 +86-15508631887 , +86-15508631887
Website: http://www.finerchem.com/
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
Tel: +86-19930503282 , +86-19930503282
Website: https://www.chemicalbook.com/manufacturer/crovell/
Company Name: Xi'an Kono chem co., Ltd.,
Tel: 029-86107037 13289246953 , 13289246953
Website: www.konochem.com
Tags:20702-77-6 Related Product Information
10236-47-2 56-53-1 614-47-1 13241-33-3 50292-00-7 6151-25-3 512-04-9 23180-57-6 520-26-3 5736-88-9 5471-51-2 4160-51-4 104-20-1 60-82-2 530-14-3 112-34-5 3516-95-8 18916-17-1