152-58-9
中文名称
脱氧可的松
英文名称
CORTEXOLONE
CAS
152-58-9
EINECS 编号
205-805-2
分子式
C21H30O4
MDL 编号
MFCD00003662
分子量
346.46
MOL 文件
152-58-9.mol
更新日期
2024/04/22 18:18:33
152-58-9 结构式
基本信息
中文别名
脱氧皮醇脱氧可的松
可托多松
皮甾酮
肾上腺素皮质甾酮
17-羥-11-去氧可體甾酮
17-羥-11-去氧皮甾酮
英文别名
11-DEOXY-17-HYDROXYCORTICOSTERONE11-DEOXYCORTISOL
11-DESOXY-17-HYDROXYCORTICOSTERONE
11-DESOXYCORTISOL
17,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
17,21-DIHYDROXYPROGESTERONE
17ALPHA,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
17ALPHA,21-DIHYDROXYPREGNA-4-ENE-3,20-DIONE
17ALPHA-HYDROXYCORTEXONE
4-PREGNEN-17,21-DIOL-3,20-DIONE
4-PREGNEN-17A 21-DIOL-3,20-DIONE
4-PREGNEN-17ALPHA,21-DIOL-3,20-DIONE
4-PREGNENE-17ALPHA,21-DIOL-3,20-DIONE
(8R,9S,10R,13S,14S,17R)-17-HYDROXY-17-(2-HYDROXY-ACETYL)-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
CORTEXOLONE
CORTODOXONE
REICHSTEIN'S COMPOUND ''S''
REICHSTEIN'S SUBSTANCE S
REICHSTEIN'S SUBSTANCE ''S''
REICHSTEIN'S SUBSTANCE 'S'
所属类别
分析化学：标准物质物理化学性质
熔点205-208 °C
沸点401.19°C (rough estimate)
密度1.22±0.1 g/cm3 (20 ºC 760 Torr)
折射率120 ° (C=1, Dioxane)
闪点9℃
储存条件Sealed in dry,Room Temperature
溶解度Dioxane (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly, Heated)
酸度系数(pKa)12?+-.0.60(Predicted)
形态固体
颜色白色至灰白色
水溶解性44.08mg/L(37 ºC)
Merck2932
InChIKeyWHBHBVVOGNECLV-OBQKJFGGSA-N
安全数据
警示词危险
危险品标志F,T
安全说明S24/25-S22
危险品运输编号UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany3
RTECS号TU5011500
海关编码2937.23.5050
毒性mouse,LD50,intravenous,100mg/kg (100mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04684,
常见问题列表
用途
脱氧可的松主要用于生化研究。应用
脱氧可的松是一种抗雄激素药物，局部用于治疗痤疮。它还在开发更高浓度的药物，用于治疗雄激素依赖性头皮脱发。
生物活性
Cortodoxone是一种糖皮质类固醇激素，可氧化为皮质醇 (Hydrocortisone) 。靶点
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Human Endogenous Metabolite
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知名试剂公司产品信息
Acros Organics
脱氧皮醇Cortexolone, 99%(152-58-9)
Sigma Aldrich
152-58-9(sigmaaldrich)TCI Shanghai
脱氧可的松Cortexolone,>98.0%(LC)(152-58-9)