| Identification | Back Directory | [Name]
Sevelamer hydrochloride | [CAS]
152751-57-0 | [Synonyms]
Sevelemar
SEVELAMER HCL
Sevelamer-001
Tianeptinic acid
SevelaMer HCL API
Sevelamer Hydrochloride
Sevelamer hydrochloride USP/EP/BP
Sevelamer hydrochloride Impurities
TIANFU-CHEM Sevelamer hydrochloride
Sevelamer hydrochloride(152751-57-0)
2-Propen-1-amine - 2-(chloromethyl)oxirane (1:1)
AllylaMine Hydrochloride-epichlorohydrin CopolyMer
SevelaMer Hydrochloride DISCONTINUED See : S256000
2-Propen-1-amine polymer with (chloromethyl)oxirane hydrochloride
(ChloroMethyl)oxirane polyMer with 2-Propen-1-aMine Hydrochloride
2-Propen-1-aMine Hydrochloride polyMer with 2-(ChloroMethyl)oxirane
2-Propen-1-amine, hydrochloride (1:1), polymer with 2-(chloromethyl)oxirane
Sevelamer hydrochloride
2-Propen-1-amine polymer with (chloromethyl)oxirane hydrochloride | [EINECS(EC#)]
682-522-4 | [Molecular Formula]
C6H12ClNO | [MOL File]
152751-57-0.mol | [Molecular Weight]
149.619 |
| Hazard Information | Back Directory | [Originator]
Renagel,Chugai Pharmaceutical | [Uses]
Sevelamer HCl is used in the treatment of hyperphosphataemia in patients suffering from chronic kidney disease. | [Uses]
Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure. | [Definition]
ChEBI: Sevelamer hydrochloride is an epoxide. | [Manufacturing Process]
Poly(allylamine hydrochloride) (50% w/w, 426 kg) was charged to a 1000 L reactor and water (200 L) was added. Sodium hydroxide solution (32% w/w,
208 kg) was added, followed by 85 L of water. The mixture was stirred for 1 h
and filtered to a 2500 L reactor. The transfer line was rinsed with water (217
kg) and acetonitrile (1300 L) added. The temperature was adjusted to 40°C
and epichlorohydrin (20 kg) added. The mixture was stirred at 40° to 50°C for
1.5 h and then heated to reflux for 16 h. The resulting product slurry may be
isolated and washed in decanter centrifuge.
| [Brand name]
Renagel (Genzyme). | [Therapeutic Function]
Antihyperphosphatemic | [Veterinary Drugs and Treatments]
Sevalamer may be useful for treating hyperphosphatemia associated
with chronic renal failure, particularly when oral aluminum
salts are not tolerated. |
|
|