| Identification | More | [Name]
ANTAZOLINE PHOSPHATE | [CAS]
154-68-7 | [Synonyms]
2-[(N-BENZYLANILINO)METHYL]-2-IMIDAZOLINE PHOSPHATE
2-(N-BENZYLANILINOMETHYL) IMIDAZOLINE PHOSPHATE
2-(N-PHENYL-N-BENZYL-AMINOMETHYL)-IMIDAZOLINE H3PO4
ANTAZOLINE H3PO4
ANTAZOLINE PHOSPHATE
ANTAZOLINE PHOSPHATE SALT
ANTISTIN PHOSPHATE
BENZYL-(4,5-DIHYDRO-1H-IMIDAZOL-2-YLMETHYL)-PHENYL-AMINE H3PO4
HISTOSAB PHOSPHATE
N-benzyl-4,5-dihydro-N-phenyl-1H-imidazole-2-methylamine monophosphate
ANTAZOLINE PHOSPHATE CRYSTALLINE
Antistine phosphate | [EINECS(EC#)]
205-831-4 | [Molecular Formula]
C17H22N3O4P | [MDL Number]
MFCD00054317 | [Molecular Weight]
363.35 | [MOL File]
154-68-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
194-198° | [storage temp. ]
Refrigerator | [solubility ]
DMSO, Methanol | [form ]
neat | [color ]
White | [Major Application]
pharmaceutical (small molecule) | [InChI]
1S/C17H19N3.H3O4P/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16;1-5(2,3)4/h1-10H,11-14H2,(H,18,19);(H3,1,2,3,4) | [InChIKey]
DUIGUKRYYAGJAF-UHFFFAOYSA-N | [SMILES]
OP(O)(O)=O.C1CN=C(CN(Cc2ccccc2)c3ccccc3)N1 | [CAS DataBase Reference]
154-68-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
2933290000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
Antazoline Phosphate acts as a histamine H1 receptor blocker, functioning as an antihistamine pharmaceutical. | [General Description]
Antazoline phosphate, 2-[(Nbenzylanilino)methyl]-2-imidazoline dihydrogen phosphate,is a bitter, white to off-white crystalline powder thatis soluble in water. It has a pKa of 10.0, and a 2% solutionhas a pH of about 4.5. Antazoline, like the ethylenediamines,contains an N-benzylanilino group linked to a basicnitrogen through a two-carbon chain.
Antazoline is less active than most of the other antihistaminicdrugs, but it is characterized by the lack of local irritation.The more soluble phosphate salt is applied topicallyto the eye in a 0.5% solution. The less soluble hydrochlorideis given orally. In addition to its use as an antihistamine, antazolinehas more than twice the local anesthetic potency ofprocaine and also exhibits anticholinergic actions. | [Biological Activity]
Imidazoline agonist; more potent than efaroxan in inducing insulin release from β cells; H1 histamine receptor antagonist. | [in vivo]
Antazoline phosphate (IP; 0.01 ml/g; 30min) as H1 receptor antagonists diminishes the anticonvulsant activity of carbamazepine and diphenylhydantoin[3]. | Animal Model: | Swiss mice[3] | | Dosage: | 0.01 mL/g | | Administration: | IP; 0.01 ml/g; 30min | | Result: | Showed some proconvulsive activity. |
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