| Identification | More | [Name]
Antazoline | [CAS]
91-75-8 | [Synonyms]
2-(N-PHENYL-N-BENZYL-AMINOMETHYL)-IMIDAZOLINE 0.5 H2SO4
albalon-a
ANTAZOLINE
ANTAZOLINE 0.5 H2SO4
BENZYL-(4,5-DIHYDRO-1H-IMIDAZOL-2-YLMETHYL)-PHENYL-AMINE 0.5 H2SO4
n-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline
1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-
2-(N-Phenyl-N-benzylaminomethyl)imidazoline
2-[(N-Benzylanilino)methyl]-2-imidazol
2-[(N-Benzylanilino)methyl]-2-imidazoline
2-Imidazoline, 2-[(N-benzylanilino)methyl]-
2-Phenyl-benzyl-amino-methylimidazolin
4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine
5512-M
Allergan A
Analergine
Antastan
Antasten
Antazolin
Antihistal | [EINECS(EC#)]
202-094-0 | [Molecular Formula]
C17H19N3 | [MDL Number]
MFCD00047013 | [Molecular Weight]
265.35 | [MOL File]
91-75-8.mol |
| Hazard Information | Back Directory | [Chemical Properties]
White, odorless crystalline powder with bitter taste. Sparingly soluble in alcohol and water; practically insoluble in benzene and ether. | [Originator]
Antistine HCl,Ciba,US,1948 | [Uses]
Antihistaminic. | [Definition]
ChEBI: A member of the class of imidazolines that is 2-aminomethyl-2-imidazoline in which the exocyclic amino hydrogens are replaced by benzyl and phenyl groups. Antazoline is only found in individuals that have taken the drug. | [Manufacturing Process]
15.4 parts of 2-chloromethylimidazoline hydrochloride, 45.8 parts of Nbenzylaniline
and 150 parts of alcohol are heated in an oil bath at 100° to
110°C. After distilling off the alcohol, the reaction mass is maintained at this
temperature for a further 3 hours and then triturated with water and 10 parts
of sodium bicarbonate. The unconsumed benzylaniline is extracted with ether
and the aqueous solution neutralized with dilute hydrochloric acid. By
evaporating this solution and extracting the residue with alcohol there is
obtained 2-(N-phenyl-N-benzylaminomethyl)imidazoline hydrochloride in the form of colorless crystals of melting point 227° to 229°C. | [Therapeutic Function]
Antihistaminic | [Clinical Use]
Antazoline is used for local application to the
eye in allergic conjunctivitis. | [Safety Profile]
Poison by ingestion, subcutaneous, and intraperitoneal routes. An eye irritant. When heated to decomposition it emits toxic fumes of NOx. |
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LGM Pharma
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HBCChem, Inc.
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