| Identification | Back Directory | [Name]
1H-Benz[e]indolium, 2-[5-[3-[6-[(3-azidopropyl)amino]-6-oxohexyl]-1,3-dihydro-1,1-dimethyl-2H-benz[e]indol-2-ylidene]-1,3-pentadien-1-yl]-1,1,3-trimethyl-, chloride (1:1) | [CAS]
1557136-25-0 | [Synonyms]
1H-Benz[e]indolium, 2-[5-[3-[6-[(3-azidopropyl)amino]-6-oxohexyl]-1,3-dihydro-1,1-dimethyl-2H-benz[e]indol-2-ylidene]-1,3-pentadien-1-yl]-1,1,3-trimethyl-, chloride (1:1) | [Molecular Formula]
C43H49ClN6O | [MOL File]
1557136-25-0.mol | [Molecular Weight]
701.36 |
| Chemical Properties | Back Directory | [solubility ]
Soluble in DMSO, DMF, DCM | [form ]
Solid | [color ]
Pink to red | [Appearance]
Dark blue solid | [ex/em]
680/698 nm (PBS buffer) | [ε(extinction coefficient)]
198000 L⋅mol−1⋅cm−1 | [Φ(quantum yield)]
0.20 |
| Hazard Information | Back Directory | [Description]
Cy5.5 azide is a functionalized cyanine dye containing an azide group which can react with alkynes for copper-catalyzed Click Chemistry. Cyanine5.5 is a far-red dye working great for live organism imaging and applications requiring low fluorescence background. | [Chemical Properties]
Appearance: Dark blue solid
ex/em: 680/698 nm (PBS buffer)
Extinction coefficient (ε): 198000 L??mol??1??cm??1
Quantum yield (Φ): 0.20 | [Uses]
Cyanine 5.5 azide (CY 5.5 azide) is a potent fluorescent dye. Cyanine 5.5 azide can label DNA. Cyanine 5.5 azide can be used for NIR live organism imaging. (λex=684 nm, λem=710 nm)[1][2]. Cyanine 5.5 azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [References]
[1] Sun H, et, al. Zwitterionic Cross-Linked Biodegradable Nanocapsules for Cancer Imaging. Langmuir. 2019 Feb 5;35(5):1440-1449. DOI:10.1021/acs.langmuir.8b01633
[2] Damaj MI, et, al. In vivo characterization of a novel inhibitor of CNS nicotinic receptors. Eur J Pharmacol. 2005 Oct 3;521(1-3):43-8. DOI:10.1016/j.ejphar.2005.06.056 |
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