| Identification | Back Directory | [Name]
THK-523 | [CAS]
1573029-17-0 | [Synonyms]
THK-523
4-(6-(2-fluoroethoxy)quinolin-2-yl)aniline
4-[6-(2-Fluoroethoxy)-2-quinolinyl]benzenamine
Benzenamine, 4-[6-(2-fluoroethoxy)-2-quinolinyl]- | [Molecular Formula]
C17H15FN2O | [MOL File]
1573029-17-0.mol | [Molecular Weight]
282.31 |
| Hazard Information | Back Directory | [Description]
THK-523 is a selective Tau ligand, selectively binding to neurofibrillary tangles and neuropils in people with Alzheimer's disease. | [Uses]
THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease[1]. | [in vivo]
THK-523 crosses the blood-brain barrier in mice and the in vivo retention rate in the brain of Tau transgenic mice increased[1]. | Animal Model: | Brain of tau transgenic mice[1] | | Dosage: | 0.35 μg/kg | | Administration: | Intravenous injection;25-30 mins | | Result: | Overexpressed Tau in brain. |
| [References]
[1] Ryuichi Harada, et al. Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology. Eur J Nucl Med Mol Imaging.?2013 Jan;40(1):125-32. DOI:10.1007/s00259-012-2261-2
[2] Michelle T Fodero-Tavoletti,?18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain.?2011 Apr;134(Pt 4):1089-100. DOI:10.1093/brain/awr038 |
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