| Identification | Back Directory | [Name]
MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2 | [CAS]
158584-09-9 | [Synonyms]
NFF-3
NFF-2
MMP SUBSTRATE-2
MCA-RPKPYA-NVA-WM-K(DNP)-NH2
MCA-RPKPVE-NVAL-WRK(DNP)-NH2
MCA-RPKPVE-NVA-WR-K(DNP)-NH2
Mca-RPKPVE-Nva-WR-Lys(Dnp)-NH2
FLUORESCENT PEPTIDE SUBSTRATE II
7-methoxycoumarin-4-acetyl-arg-pro-*lys-pro-val-G
7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-*LYS- PRO-VAL-GLU
MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2
MCA-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-LYS(DNP)-NH2
MCA-ARG-PRO-LYS-PRO-VAL-GLU-NVAL-TRP-ARG-LYS(DNP)-NH2
MCA-ARG-PRO-LYS-PRO-VAL-GLU-NVAL-TRP-ARG-LYS(NDP)-NH2
MOCAC-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS(DNP)-NH2
MOCAC-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-LYS(DNP)-NH2
MCA-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-LYS: DNP-NH2 [MCA-RPKPVE-NVA-WRK: DNP-NH2]
MCA-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-LYS: DNP-NH2 [MCA-RPKPYA-NVA-WM-K: DNP-NH2]
7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-LYS-PRO-VAL-GLU-NVA-TRP-ARG-(2,4-DINITROPHENYL)-LYS AMIDE
7-METHOXYCOUMARIN-4-ACETYL-ARG-PRO-LYS-PRO-TYR-ALA-NVA-TRP-MET-(2,4-DINITROPHENYL)-LYS AMIDE
(7-METHOXYCOUMARIN-4-YL)ACETYL-L-ARGINYL-L-PROLYL-L-LYSYL-L-PROLYL-L-VALYL-L-GLUTAMYL-L-NORVALYL-L-TRYPTOPHYL-L-ARGINYL-N-EPSILON-(2,4-DINITROPHENYL)-L-LYSINE AMIDE
(7-METHOXYCOUMARIN-4-YL)ACETYL-L-ARGINYL-L-PROLYL-L-LYSYL-L-PROLYL-L-TYROSYL-L-ALANYL-L-NORVALYL-L-TRYPTOPHYL-L-METHIONYL-N-EPSILON-(2,4-DINITROPHENYL)-L-LYSINE AMIDE
L-Lysinamide, N2-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-valyl-L-α-glutamyl-L-norvalyl-L-tryptophyl-L-arginyl-N6-(2,4-dinitrophenyl)- | [Molecular Formula]
C78H110N22O20 | [MDL Number]
MFCD00671420 | [MOL File]
158584-09-9.mol | [Molecular Weight]
1675.84 |
| Chemical Properties | Back Directory | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMF: 25 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: slightly soluble | [form ]
A crystalline solid | [pka]
4.44±0.10(Predicted) | [color ]
yellow | [Sequence]
{Mca}-Arg-Pro-Lys-Pro-Val-Glu-{Nva}-Trp-Arg-Lys(DNP)-NH2 |
| Hazard Information | Back Directory | [Uses]
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity[1]. | [Biological Activity]
Cell permeable: no''Primary Target
Matrix Metalloproteinases (MMPs)''Product does not compete with ATP.''Reversible: no''kcat/Km = 5.9 x 104 M-1sec-1 as substrates for MMP-3 (stromelysin-1) | [IC 50]
MMP-3; MMP-10 | [References]
[1] Giricz O, et al. Comparison of metalloproteinase protein and activity profiling. Anal Biochem. 2011 Feb 1;409(1):37-45. DOI:10.1016/j.ab.2010.09.040 |
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