| Identification | Back Directory | [Name]
AC-IEPD-AMC | [CAS]
216757-33-4 | [Synonyms]
AC-IEPD-AMC
AC-ILE-GLU-PRO-ASP-AMC
GRANZYME B SUBSTRATE IX, FLUOROGENIC
AC-ILE-GLU-PRO-ASP-7-AMINO-4-METHYLCOUMARIN
N-ACETYL-ILE-GLU-PRO-ASP-7-AMIDO-4-METHYLCOUMARIN
N-Acetyl-L-isoleucyl-L-α-glutamyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine
L-α-Asparagine, N-acetyl-L-isoleucyl-L-α-glutamyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
N-Acetyl-L-isoleucyl-L-alpha-glutamyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-alpha-asparagine | [Molecular Formula]
C32H41N5O11 | [MDL Number]
MFCD02259622 | [MOL File]
216757-33-4.mol | [Molecular Weight]
671.69 |
| Chemical Properties | Back Directory | [Boiling point ]
1116.0±65.0 °C(Predicted) | [density ]
1.366±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO/DMF: 1 mg/mL | [form ]
powder | [pka]
4.12±0.10(Predicted) | [Sequence]
Ac-Ile-Glu-Pro-Asp-{AMC} | [InChIKey]
XDMHHBKPMUGLEA-MNTOYCOOSA-N | [SMILES]
CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2 |
| Hazard Information | Back Directory | [Uses]
Ac-IEPD-AMC is a fluorogenic substrate for the determination of protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal[1]. | [References]
[1] Scott JI, et, al. A Functional Chemiluminescent Probe for in Vivo Imaging of Natural Killer Cell Activity Against Tumours. Angew Chem Int Ed Engl. 2021 Mar 8;60(11):5699-5703. DOI:10.1002/anie.202011429 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|