| Identification | Back Directory | [Name]
DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS | [CAS]
161877-70-9 | [Synonyms]
ICE SUBSTRATE II
DABCYL-YVADAPV-EDANS
CASPASE 1 (ICE) SUBSTRATE
IL-1B CONVERTING ENZYME SUBSTRATE II
DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS
IL-1-BETA CONVERTING ENZYME SUBSTRATE II
Caspase 1 (ICE) substrate for FRET assays
INTERLEUKIN-1BETA CONVERTING ENZYME SUBSTRATE II
DABCYL-Tyr-Val-Ala-Asp-Ala-Pro-Val-EDANS trifluoroacetate salt
4-(4-DIMETHYLAMINOPHENYLAZO)BENZOYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-5-[(2-AMINOETHYL)AMINO]-NAPHTHALENE-1-SULFONIC ACID
4-(4'-dimethylaminophenylazo)benzoyl-tyrosyl-valyl-alanyl-aspartyl-alanyl-prolyl-valyl-5((2-aminoethyl)amino)naphthalene-1-sulfonic acid
L-Valinamide,N-[4-[[4-(dimethylamino)phenyl]azo]benzoyl]-L-tyrosyl-L-valyl-L-alanyl-L-α-aspartyl-L-alanyl-L-prolyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-
L-Valinamide, N-[4-[[4-(dimethylamino)phenyl]azo]benzoyl]-L-tyrosyl-L-valyl-L-alanyl-L-α-aspartyl-L-alanyl-L-prolyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]- (9CI) | [Molecular Formula]
C61H76N12O14S | [MDL Number]
MFCD01076565 | [MOL File]
161877-70-9.mol | [Molecular Weight]
1233.39 |
| Chemical Properties | Back Directory | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C
| [solubility ]
5% NH3 (Aqueous): 1 mg/ml | [form ]
A lyophilized powder | [pka]
-0.26±0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
Dabcyl-YVADAPV-EDANS is a fluorogenic substrate for caspase-1. Upon enzymatic cleavage by caspase-1. EDANS is released upon enzymatic cleavage by caspase-1 at the Ala-Ser site, of which the fluorescence can be used to quantify caspase-1 activity. | [Uses]
Dabcyl-YVADAPV-EDANS is a fluorogenic interleukin-1β converting enzyme (ICE) substrate for measuring ICE-like protease activity. Dabcyl-YVADAPV-EDANS detects fluorescence at 360 nm excitation and 480 nm emission wavelengths. ICE-like protease is a critical mediator of K+ deprivation-induced apoptosis of cerebellar granule neurons[1]. | [References]
[1] Schulz JB, et al. Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species. J Neurosci. 1996 Aug 1;16(15):4696-706. DOI:10.1523/JNEUROSCI.16-15-04696.1996 | [Sequene]
Dabcyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-edans |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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