| Identification | Back Directory | [Name]
H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH | [CAS]
199999-60-5 | [Synonyms]
WP9QY
TNF-α Antagonist
TNF-α Antagonist
WP9QY, W9, YCWSQYLCY
TNF-ALPHA ANTAGONIST
TUMOR NECROSIS FACTOR-ALPHA ANTAGONIST
H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH
161:PN:WO2010033207 SEQID:210 claimed protein
H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH, (Disulfide bond)
H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH,(DISULFIDE BOND BETWEEN CYS2 AND CYS 8
H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH,(Disulfide bond between Cys2 and Cys 8
L-Tyrosine, L-tyrosyl-L-cysteinyl-L-tryptophyl-L-seryl-L-glutaminyl-L-tyrosyl-L-leucyl-L-cysteinyl-, cyclic (2→8)-disulfide | [Molecular Formula]
C58H71N11O15S2 | [MDL Number]
MFCD02259683 | [MOL File]
199999-60-5.mol | [Molecular Weight]
1226.38 |
| Chemical Properties | Back Directory | [Boiling point ]
1692.1±65.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C
| [solubility ]
DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml | [form ]
A crystalline solid | [pka]
3.05±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
water: 1mg/mL
5% acetic acid: 5mg/mL | [Sequence]
Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr (Disulfide bridge:Cys2-Cys8) |
| Hazard Information | Back Directory | [Uses]
WP9QY, TNF-a Antagonist, TNF-a Antagonist is a biological active peptide. (This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.) | [Biological Activity]
Cell permeable: no''Product does not compete with ATP.''Reversible: no''Target IC50: 5 μM as TNF-α antagonist | [References]
[1] Lin CC, et al. Functional PEG-peptide hydrogels to modulate local inflammation induced by the pro-inflammatory cytokine TNFalpha. Biomaterials. 2009 Oct;30(28):4907-14. DOI:10.1016/j.biomaterials.2009.05.083 |
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