| Identification | Back Directory | [Name]
-Defensin-2 (human) (trifluoroacetate salt) | [CAS]
372146-20-8 | [Synonyms]
Human β-defensin-2
-Defensin-2 (human) (trifluoroacetate salt) | [Molecular Formula]
C190H306F3N55O52S6 | [MOL File]
372146-20-8.mol | [Molecular Weight]
4442.19 |
| Chemical Properties | Back Directory | [Sequence]
Gly-Ile-Gly-Asp-Pro-Val-Thr-Cys-Leu-Lys-Ser-Gly-Ala-Ile-Cys-His-Pro-Val-Phe-Cys-Pro-Arg-Arg-Tyr-Lys-Gln-Ile-Gly-Thr-Cys-Gly-Leu-Pro-Gly-Thr-Lys-Cys-Cys-Lys-Lys-Pro (Disulfide bridge:Cys8-Cys37; Cys15-Cys30; Cys20-Cys38) |
| Hazard Information | Back Directory | [Uses]
Human β-defensin-2 (HβD-2) is a small cysteine-rich cationic skin-antimicrobial peptide?(SAP) produced by a number of epithelial cells.Human β-defensin-2 has antimicrobial activity against gram-negative bacteria and Candida, but not gram-positive Staphylococcus aureus[1]. Human β-defensin-2 can be used for the study of colitis[2]. | [References]
[1] J M Schr?der, et al. Human beta-defensin-2. Int J Biochem Cell Biol DOI:10.1016/s1357-2725(99)00013-8
[2] Louis Koeninger, et al. Human β-Defensin 2 Mediated Immune Modulation as Treatment for Experimental Colitis. Front Immunol. 2020 Jan 31;11:93. DOI:10.3389/fimmu.2020.00093 |
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