| Identification | Back Directory | [Name]
COG-1410 | [CAS]
878009-24-6 | [Synonyms]
COG-1410
L-Leucinamide, N-acetyl-L-alanyl-L-seryl-2-methylalanyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-2-methylalanyl-L-lysyl-L-arginyl-L-leucyl- | [Molecular Formula]
C64H121N21O14 | [MDL Number]
MFCD18072264 | [MOL File]
878009-24-6.mol | [Molecular Weight]
1408.78 |
| Chemical Properties | Back Directory | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light, stored under nitrogen | [solubility ]
DMSO : 100 mg/mL (70.98 mM; Need ultrasonic) | [form ]
Solid | [pka]
12.62±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease[1][2]. | [in vivo]
COG1410 (0.3-0.6 mg/kg; a single i.v.) exhibits significant improvement on a short term test of vestibulomotor function and on a long term test of spatial learning and memory in mice[1].
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COG1410 (0.8 mg/kg; a single i.v.) improves vestibulomotor function, decreases poststroke locomotor asymmetry, and decreases infarct volume of the ipsilateral hemisphere in rats[2]. | Animal Model: | Male C57Bl/6J mice (12-16 weeks) with TBI[1] | | Dosage: | 0.3, 0.6 mg/kg | | Administration: | A single i.v. by tail vein | | Result: | Improved motor function on days 1-5 postinjury.
Significantly improved cognitive impairment.
Reduced the number of injured hippocampal neurons.
Suppressed the microglial activation.
|
| [storage]
Store at -20°C, protect from light, stored under nitrogen | [References]
[1] Laskowitz DT, et, al. COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. J Neurotrauma. 2007 Jul;24(7):1093-107. DOI:10.1089/neu.2006.0192
[2] Tukhovskaya EA, et, al. COG1410, a novel apolipoprotein-E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia. J Neurosci Res. 2009 Feb 15;87(3):677-82. DOI:10.1002/jnr.21874
[3] Kuai L, et, al. Apolipoprotein E-Mimetic Peptide COG1410 Enhances Retinal Ganglion Cell Survival by Attenuating Inflammation and Apoptosis Following TONI. Front Neurosci. 2019 Sep 13;13:980. DOI:10.3389/fnins.2019.00980 |
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