| Identification | Back Directory | [Name]
b-Alanine,N-[[(4R)-2,2,5,5-tetramethyl-1,3-dioxan-4-yl]carbonyl]-,(1S,2S)-2-[[[(2,2-dimethylpropyl)nonylamino]carbonyl]amino]cyclohexyl ester | [CAS]
162490-89-3 | [Synonyms]
F-1394
[(1S,2S)-2-[[2,2-dimethylpropyl(nonyl)carbamoyl]amino]cyclohexyl]3-[[(4R)-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl]amino]propanoate
b-Alanine,N-[[(4R)-2,2,5,5-tetramethyl-1,3-dioxan-4-yl]carbonyl]-,(1S,2S)-2-[[[(2,2-dimethylpropyl)nonylamino]carbonyl]amino]cyclohexyl ester
β-Alanine, N-[[(4R)-2,2,5,5-tetramethyl-1,3-dioxan-4-yl]carbonyl]-, (1S,2S)-2-[[[(2,2-dimethylpropyl)nonylamino]carbonyl]amino]cyclohexyl ester | [Molecular Formula]
C33H61N3O6 | [MOL File]
162490-89-3.mol | [Molecular Weight]
595.854 |
| Chemical Properties | Back Directory | [Boiling point ]
727.2±60.0 °C(Predicted) | [density ]
1.05±0.1 g/cm3(Predicted) | [storage temp. ]
-10 to -25°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
(Powder or solid or semi-solid or liquid) | [pka]
13.12±0.40(Predicted) | [color ]
white to beige | [InChIKey]
NWLFOBZKYXKBOF-NSVAZKTRSA-N | [SMILES]
CCCCCCCCCN(C(N[C@H]1CCCC[C@@H]1OC(CCNC([C@H]2C(C)(COC(C)(O2)C)C)=O)=O)=O)CC(C)(C)C |
| Hazard Information | Back Directory | [Uses]
F-1394 is an orally active acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor that inhibits dietary cholesterol absorption in mice. F-1394 can be used in cardiovascular disease research[1]. | [Biological Activity]
F1394 is an orally availablepotent and selective Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor th at reduces plaque foam cell formation without inflammatory or toxic effects. | [References]
[1] Kusunoki J, et al. Hypocholesterolemic action and prevention of cholesterol absorption via the gut by F-1394, a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, in cholesterol diet-fed rats. Jpn J Pharmacol. 1995 Sep;69(1):53-60. DOI:10.1254/jjp.69.53 |
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