| Identification | More | [Name]
(R)-Boc-Nipecotic acid | [CAS]
163438-09-3 | [Synonyms]
1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-3-carboxylic acid
BOC-D-NIP-OH
BOC-R-NIP-OH
D-1-BOC-NIPECOTIC ACID
N-BOC-(R)-NIPECOTIC ACID
(R)-1-BOC-NIPECOTIC ACID
(R)-1-BOC-PIPERIDINE-3-CARBOXYLIC ACID
(R)-1-(TERT-BUTOXYCARBONYL)PIPERIDINE-3-CARBOXYLIC ACID
(R)-BOC-NIP
(R)-BOC-NIPECOTIC ACID
(r)-boc-nip-oh
(R)-(-)-N-BOC-NIPECOTIC ACID
(R)-N-BOC-PIPERIDINE-3-CARBOXYLIC ACID
(R)-N-TERT-BUTYLOXYCARBONYL-NIPECOTIC ACID
(R)-N-TERT-BUTYLOXYCARBONYL-PIPERIDINE-3-CARBOXYLIC ACID
(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
(R)-Boc-Piperidine-3-Carboxylic Acid
(R)-BOC-NIPECOTIC ACID: (R)-N-BOC-PIPERIDINE-3-CARBOXYLIC ACID
(R)-N-BOC-PIPERIDINE-3-CARBOXYLIC ACID ,98%
(R)-N-t-Butyloxycarbonyl-nipecotic acid, (R)-N-t-butyloxycarbonyl-piperidine-3-carboxylic acid | [Molecular Formula]
C11H19NO4 | [MDL Number]
MFCD02179173 | [Molecular Weight]
229.27 | [MOL File]
163438-09-3.mol |
| Chemical Properties | Back Directory | [Boiling point ]
353.2±35.0 °C(Predicted) | [density ]
1.164±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Crystalline Powder | [pka]
4.49±0.20(Predicted) | [color ]
White | [BRN ]
5539297 | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-5-8(7-12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/t8-/m1/s1 | [InChIKey]
NXILIHONWRXHFA-MRVPVSSYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCC[C@@H](C(O)=O)C1 | [CAS DataBase Reference]
163438-09-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P305+P351+P338-P280a-P304+P340-P405-P501a | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
1-Boc-D-nipecotic acid is used as an organic chemical synthesis intermediate. | [reaction suitability]
reaction type: Boc solid-phase peptide synthesis | [Synthesis]
Step 1: 3-Piperidinecarboxylic acid (1.05 g, 8.1 mmol) was dissolved in a solvent mixture of tetrahydrofuran (20 mL) and water (20 mL). Di-tert-butyl dicarbonate (2.48 g, 11.4 mmol) and sodium bicarbonate (0.96 g, 11.4 mmol) were added. The reaction mixture was stirred at room temperature overnight. After the reaction was completed, the mixture was diluted with water and ether. The aqueous layer was adjusted to pH=2 with concentrated hydrochloric acid and then extracted with dichloromethane. The organic layers were combined, dried over sodium sulfate, and concentrated to give (R)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (1.8 g, 97% yield). retention time by LCMS (Condition A) = 3.26 min, and m/z = 230 ([M+H]+) was observed by mass spectrum. | [References]
[1] Patent: WO2005/14540, 2005, A1. Location in patent: Page/Page column 39
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 19, p. 6456 - 6468
[3] Patent: WO2010/120889, 2010, A1. Location in patent: Page/Page column 55; 60 |
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Alfa Aesar
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Energy Chemical
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Jia Xing Isenchem Co.,Ltd
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