| Identification | More | [Name]
1-Boc-5-aminoindole | [CAS]
166104-20-7 | [Synonyms]
1-BOC-5-AMINOINDOLE
5-AMINO-1-BOC-BENZIMIDAZOLE
5-AMINO-1-BOC-BENZOIMIDAZOLE
5-AMINO-BENZOIMIDAZOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
5-AMINO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
tert-butyl 5-amino-1H-indole-1-carboxylate
5-Aminoindole, N1-BOC protected
1-BOC-5-AMINOINDOLE, 98+%
5-AMINOINDOLE-1-BOC
N-Boc-5-Aminoindole | [Molecular Formula]
C13H16N2O2 | [MDL Number]
MFCD04114746 | [Molecular Weight]
232.28 | [MOL File]
166104-20-7.mol |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of N-Boc-5-aminoindole from tert-butyl 5-nitro-1H-indole-1-carboxylate: tert-butyl 5-nitro-1H-indole-1-carboxylate (525 mg, 2.0 mmol) was dissolved in ethyl acetate (8 mL), and 10% palladium-carbon-catalyst (50 mg) was added. The reaction mixture was stirred overnight at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by suction filtration and the filtrate was concentrated under reduced pressure to afford the white solid product N-Boc-5-aminoindole (469 mg, 100% yield). | [References]
[1] Patent: CN104311541, 2017, B. Location in patent: Paragraph 0164; 0165
[2] Patent: US2009/247568, 2009, A1. Location in patent: Page/Page column 36
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 15, p. 6273 - 6277
[4] Synthetic Communications, 2006, vol. 36, # 14, p. 2069 - 2077
[5] Journal of Medicinal Chemistry, 2011, vol. 54, # 4, p. 1106 - 1110 |
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