| Identification | Back Directory | [Name]
N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER | [CAS]
1690-75-1 | [Synonyms]
Methyl N-methylisonipecotinate
1-methylisonipecotic acid methyl ester
Methyl 1-Methyl-4-piperidinecarboxylate
METHYL 1-METHYLPIPERIDINE-4-CARBOXYLATE
Methyl N-methyl-4-piperidinecarboxylate
Methyl N-methylPiperidine-4-carboxylate1
N-methyl piperidine-4-carboxylate, methyl ester
Methyl-4-piperidine carboxylic acid methyl ester
N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER
N-METHYLPIPERIDINE-4-CARBOXYLIC ACID METHYL ESTER
1-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER
1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID METHYL ESTER
4-Piperidinecarboxylic acid, 1-methyl-, methyl ester
Piperidine derivative Methyl N-methyl piperidine-4-carboxylate
Piperidine derivative CAS NO.1690-75-1 Methyl N-methyl piperidine-4-carboxylate | [EINECS(EC#)]
-0 | [Molecular Formula]
C8H15NO2 | [MDL Number]
MFCD06658483 | [MOL File]
1690-75-1.mol | [Molecular Weight]
157.21 |
| Chemical Properties | Back Directory | [Boiling point ]
202°C(lit.) | [density ]
1.0806 (rough estimate) | [refractive index ]
1.4520 to 1.4560 | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
clear liquid | [pka]
8.43±0.10(Predicted) | [color ]
Colorless to Light yellow | [InChI]
InChI=1S/C8H15NO2/c1-9-5-3-7(4-6-9)8(10)11-2/h7H,3-6H2,1-2H3 | [InChIKey]
KYAOKPRJTMFBTQ-UHFFFAOYSA-N | [SMILES]
N1(C)CCC(C(OC)=O)CC1 |
| Hazard Information | Back Directory | [Synthesis]
To a stirred solution of methyl 4-piperidinecarboxylate (7.00 mmol) in methanol (25 mL) was sequentially added formic acid (5.52 g, 12.00 mmol) and 40% aqueous formaldehyde (2.67 g, 35.00 mmol). The reaction mixture was heated to reflux. after 3 h, the reaction mixture was cooled and concentrated under reduced pressure. The residue was dissolved in water, alkalized with sodium bicarbonate solution and extracted with dichloromethane (3 x 30 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give methyl N-methyl-4-piperidinecarboxylate in brown liquid form (yield: 910 mg). NMR hydrogen spectrum (270 MHz, CDCl3, TMS as internal standard) δ: 1.69-2.03 (6H, m), 2.23-2.32 (4H, m), 2.78-2.83 (2H, m), 3.68 (3H, s). Mass spectrum (APCI) m/z: 158 ([M+H]+, 100%), 126 (C7H12ON, 33%). | [References]
[1] Patent: WO2004/58259, 2004, A1. Location in patent: Page/Page column 26-27 |
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