| Identification | More | [Name]
1-Methyl-3-piperidinemethanol | [CAS]
7583-53-1 | [Synonyms]
1-METHYL-3-PIPERIDINEMETHANOL
1-METHYLPIPERIDINE-3-METHANOL
3-HYDROXYMETHYL-1-METHYLPIPERIDINE
3-HYDROXYMETHYL-N-METHYLPIPERIDINE
N-METHYL-3-PIPERIDINE METHANOL
N-METHYLPIPERIDINE-3-CARBINOL
(1-Methyl-3-piperidinyl)methanol
1-Methyl-3-hydroxymethylpiperidine
3-Piperidinemethanol, 1-methyl-
(1-methyl-3-piperidyl)methanol
3-(Hydroxymethyl)-1-methylpiperidine 96%
(1-Methylpiperidin-3-yl)methanol
N-Methylpiperidine-3-methanol | [EINECS(EC#)]
231-488-5 | [Molecular Formula]
C7H15NO | [MDL Number]
MFCD00006497 | [Molecular Weight]
129.2 | [MOL File]
7583-53-1.mol |
| Questions And Answer | Back Directory | [Synthesis]
Under argon protection, appropriate amounts of lithium aluminum hydride (2 mol) and dry tetrahydrofuran were added to a dry reaction flask. The reaction system was then cooled to zero degrees Celsius, followed by the addition of the precursor compound ester (1 mol). After the addition was complete, the reaction system was heated to 40-50 degrees Celsius and stirred for 2 hours, then stirred overnight at room temperature. After the reaction was complete, the reaction was quenched by adding H₂O, and a cooling NaOH aqueous solution was added as needed. The solution was then filtered, the solid was washed with dry tetrahydrofuran, the filtrate was dried with anhydrous sodium sulfate, and the sodium sulfate solid was removed by filtration. The filtrate was concentrated under vacuum to obtain the target product, 1-Methyl-3-piperidinemethanol. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [PackingGroup ]
III | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to yellow liquid | [Uses]
Hydroxymethyl-N-methylpiperidine is used in the preparation of pyrimidines as FGFR3 tyrosine kinase inhibitors as well as for potent pyrazine c-Src inhibitors in the treatment of ischemic stroke. |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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Energy Chemical
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Jia Xing Isenchem Co.,Ltd
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