ChemicalBook--->CAS DataBase List--->1694-06-0

1694-06-0

1694-06-0 Structure

1694-06-0 Structure
IdentificationMore
[Name]

4-Methylphenylsulfonylurea
[CAS]

1694-06-0
[Synonyms]

4-METHYLPHENYLSULFONYLUREA
4-TOLUENESULFONYLUREA
P-TOLUENESULFONYLUREA
P-TOLUENESULPHONYLUREA
P-TOLYLSULFONGLUREA
P-TOLYLSULFONYLUREA
4-tolylsulfonylurea
N-(Aminocarbonyl)-4-methylbenzensulfona-mide
p-Tolysulfonylurea
4-toluenesulphonyl urea
N-(aminocarbonyl)-4-methylbenzenesulphonamide
para-Toluenesulphonyl urea
p-Tolune sulfonyl carbamide
P-TOLUENE SULFONYCARBAMIDE
N-(4-Toluenesulfonyl)-urea
P-TOLYLSULFONYLCARBAMIDE
N-(p-Methylphenylsulfonyl)urea
N-(p-Tolylsulfonyl)urea
[EINECS(EC#)]

216-900-3
[Molecular Formula]

C8H10N2O3S
[MDL Number]

MFCD00196522
[Molecular Weight]

214.24
[MOL File]

1694-06-0.mol
Chemical PropertiesBack Directory
[Appearance]

white crystalline powder
[Melting point ]

196-198 °C
[density ]

1.3844 (rough estimate)
[refractive index ]

1.5690 (estimate)
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

Solid
[pka]

5.07±0.10(Predicted)
[color ]

White to Off-White
[Water Solubility ]

777.9mg/L(37 ºC)
[InChI]

InChI=1S/C8H10N2O3S/c1-6-2-4-7(5-3-6)14(12,13)10-8(9)11/h2-5H,1H3,(H3,9,10,11)
[InChIKey]

RUTYWCZSEBLPAK-UHFFFAOYSA-N
[SMILES]

C1(S(NC(N)=O)(=O)=O)=CC=C(C)C=C1
[CAS DataBase Reference]

1694-06-0(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

C
[Risk Statements ]

R34:Causes burns.
[Safety Statements ]

S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
[WGK Germany ]

WGK 3
[HS Code ]

2935.90.9500
[REACH Registrations]

Active
[Storage Class]

11 - Combustible Solids
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Tosyl chloride-->p-Toluenesulfonamide-->hydroxy-[[N-(4-methylphenyl)sulfonylcarbamimidoyl]amino]-oxo-azanium-->p-Toluenesulfonyl Isocyanate-->Sodium cyanate-->Urea-->Azodicarbonamide-->Potassium cyanate
[Preparation Products]

Gliclazide
Hazard InformationBack Directory
[Chemical Properties]

white crystalline powder
[Uses]

4-Methylphenylsulfonylurea can be used as pharmaceutical intermediate.
[Uses]

4-Methylphenylsulfonylurea is used in the synthesis of Glyburide (G598350), a second generation sulfonylurea with hypoglycemic activity. Glyburide is an antidiabetic agent.
[Uses]

N-(p-Toluenesulfonyl)urea is used in the synthesis of Glyburide (G598350), a second generation sulfonylurea with hypoglycemic activity. Glyburide is an antidiabetic agent.
[Safety]

4-Methylphenylsulfonylurea is irritant and harmful if swallowed. Contact may cause skin irritation and severe eye irritation. Inhalation may cause respiratory tract irritation.
Spectrum DetailBack Directory
[Spectrum Detail]

4-Methylphenylsulfonylurea(1694-06-0)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

p-Toluenesulfonylurea, 98%(1694-06-0)
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