| Identification | More | [Name]
Dropropizine | [CAS]
17692-31-8 | [Synonyms]
1,2-PROPANEDIOL, 3-(4-PHENYL-1-PIPERAZINYL)-
3-[4-PHENYL-1-PIPERAZINYL]-1,2-PROPANEDIOL
(+/-)-DROPROPIZINE
DROPROPIZINE
LABOTEST-BB LT00771927
3-(4-phenyl-1-piperazinyl)-2-propanediol
catabex
dipropizine
ditustat
dopropizin
katril
larylin
ribex
tussilex
3-(4-phenylpiperazin-1-yl)propane-1,2-diol
3-(4-Phenyl-1-piperazinyl)1,2-
3-(4-Phenyl-1-piperazinyl)-1，2-pmpanediol
gevotuss
UCB-1967 | [EINECS(EC#)]
241-683-7 | [Molecular Formula]
C13H20N2O2 | [MDL Number]
MFCD00079124 | [Molecular Weight]
236.31 | [MOL File]
17692-31-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
105° (Morren); mp 108° (Bourdais) | [Boiling point ]
205 °C(Press: 1 Torr) | [density ]
1.168±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Sparingly), Methanol (Slightly) | [form ]
neat | [pka]
14.21±0.20(Predicted) | [color ]
White to Off-White | [CAS DataBase Reference]
17692-31-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
TZ1074800
| [Toxicity]
LD50 in rats (mg/kg): 200 i.v., 750 orally (Morren) |
| Hazard Information | Back Directory | [Originator]
Ribex,Formenti | [Uses]
antitussive | [Uses]
Dropropizine is a cough suppressant and central sedative therapeutic agent. | [Definition]
ChEBI: 3-(4-phenyl-1-piperazinyl)propane-1,2-diol is a member of piperazines. | [Manufacturing Process]
34 g 1,2-epoxy-3-hydroxypropane (glycide) in 50 ml of water were added to
64.8 g 1-phenylpiperazine in 80 ml of ethanol at the temperature not higher
50°C. The mixture was stood at night, then it was evaporated to dryness in
vacuum and the stark product was recrystallized from 100 ml of acetone to
give 60 g 1-phenyl-4-(2,3-dihydroxypropyl)piperazine (dropropizine) MP
105°C; BP 205°C/1 mm Hg. | [Therapeutic Function]
Antitussive |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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